The Proof with Simon Hill

The single most important blood test to know your risk of cardiovascular disease | ApoB Masterclass

268 snips
May 27, 2024
Top experts Dr Thomas Dayspring, Dr William Cromwell, Danny Lennon, Dr Alan Flanagan, and Dr Gil Carvalho discuss ApoB, a crucial marker for heart disease risk. They cover its impact on LDL particles, atherosclerosis, and longevity. The episode explores measuring ApoB, normal levels, causes of elevation, saturated fats, and reliability over LDL cholesterol.
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INSIGHT

Lipoprotein Synthesis

  • Lipoproteins are synthesized in the intestines and liver, but HDLs self-assemble in plasma.
  • HDLs are distinct due to their protein, ApoA1, unlike ApoB in other lipoproteins.
INSIGHT

Chylomicron Role

  • Chylomicrons, formed in the intestine, transport dietary fats and cholesterol through the lymphatic system.
  • They deliver triglycerides to muscles and have a short lifespan, being cleared by the liver.
INSIGHT

VLDL and LDL Functions

  • VLDLs, produced by the liver, function similarly to chylomicrons but are smaller.
  • LDLs primarily facilitate reverse cholesterol transport by accepting cholesterol from HDLs.
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