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FoundMyFitness
#062 Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks
Dec 22, 2020
Dr. Steve Horvath, a UCLA genetics expert, discusses groundbreaking advances in epigenetic aging. He explains how his Horvath Aging Clock predicts biological age and lifespan through DNA methylation. The conversation delves into the differences between PhenoAge and GrimAge clocks, offering insights into genetic factors influencing aging. He reveals that vitamin D may reverse epigenetic age, while omega-3 could slow the GrimAge clock. With ongoing research, Horvath highlights exciting potential interventions aimed at extending healthspan.
01:33:59
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Quick takeaways
- Epigenetic clocks accurately quantify aging based on DNA methylation patterns, predicting both chronological age and health span.
- Genetics significantly impact aging rates, with certain populations aging slower despite higher disease risks, emphasizing genetic influences on aging.
Deep dives
Importance of Epigenetic Clocks in Measuring Aging
Epigenetic clocks, like the Horvath Epigenetic Aging Clock, play a crucial role in measuring aging by accurately quantifying chronological and biological age based on methylation patterns in DNA. These clocks, such as the Grim Age clock, not only predict chronological age but also health span, time to disease onset, and even life span. They provide insights into predicting diseases like cancer and heart disease, offering valuable information that traditional markers like telomere length may not capture effectively.
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