FoundMyFitness #062 Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks
Dec 22, 2020
Dr. Steve Horvath, a UCLA genetics expert, discusses groundbreaking advances in epigenetic aging. He explains how his Horvath Aging Clock predicts biological age and lifespan through DNA methylation. The conversation delves into the differences between PhenoAge and GrimAge clocks, offering insights into genetic factors influencing aging. He reveals that vitamin D may reverse epigenetic age, while omega-3 could slow the GrimAge clock. With ongoing research, Horvath highlights exciting potential interventions aimed at extending healthspan.
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Pan-Tissue Clock Accuracy
- The Horvath aging clock, or pan-tissue clock, is the most accurate molecular measure of age.
- It applies to all cells with DNA and can predict chronological age from various samples.
Methylation Data Reliability
- Methylation data from DNA remains reliable even after exposure to harsh conditions.
- This makes it a useful tool for various applications, including forensics.
Epigenetic Clocks and Lifespan
- Some epigenetic clocks measure chronological age, while others predict lifespan and healthspan.
- These different clocks serve distinct purposes in aging research and intervention trials.