Unraveling the Science of Aging

This chapter explores the intricate relationship between trial design, primary outcomes, and surrogate markers in medical research, highlighting the importance of intrinsic biomarkers like the GrimAge clock. It examines the impact of sleep quality on epigenetic aging and heart health, supported by findings from the Women's Health Initiative, while also discussing cellular senescence and genomic methylation patterns. The discussion underscores the evolving intersection of developmental biology and aging, revealing how epigenetic clocks provide insight into healthspan and longevity.

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