Zone 2 Training and Cancer Metabolism: The Science Behind Peak Metabolic Health | Dr Inigo San Millan

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Feb 11, 2025

Dr. Inigo San Millan, a leading expert in metabolic health and exercise science, discusses the transformative role of lactate in both athletic performance and cancer metabolism. He emphasizes the benefits of Zone 2 training for boosting mitochondrial function and longevity. The conversation explores how skeletal muscle can aid in cancer prevention and the exciting potential of engineered nanoparticles in targeting cancer cells. San Millan also advocates for more rigorous physical activity guidelines to enhance health outcomes, especially for cancer patients.

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INSIGHT

Elite Athletes and Cancer

Elite athletes' muscles offer clues about cancer, as skeletal muscle is the body's largest organ yet rarely develops cancer.
Studying athletes with superior skeletal muscle may offer insights into cancer prevention.

INSIGHT

Myokines and Cancer

Muscle-derived exosomes (myokines) may play a role in cancer.
These myokines could potentially protect against cancer or counteract cancer-derived exosomes.

ANECDOTE

Inspiration from Otto Warburg

Dr. San Millan was inspired by Otto Warburg's research on lactate's role in cancer.
Louisa Nicola read "Rendezvous" by Sam Apple, a book about Otto Warburg.

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Dr. Inigo San Milan: Leading Expert in Metabolism, Exercise Physiology, and Cancer Research

Dr. Inigo San Milan is a globally recognized expert in metabolic health, exercise science, Zone 2 training, mitochondrial function, and cancer metabolism.

His groundbreaking research has transformed the understanding of lactate, highlighting its role not just in athletic performance but also in metabolic diseases, cancer progression, and longevity. As a strong advocate of Zone 2 training, Dr. San Milan has demonstrated how it boosts mitochondrial efficiency, improves endurance, enhances fat metabolism, and supports overall healthspan.

His pioneering approach explores cancer treatment through metabolic optimization, shifting the focus from traditional gene-targeted therapies to cellular energy balance and metabolic interventions. Dr. San Milan’s work provides a science-backed strategy for disease prevention, peak performance, and longevity through targeted metabolic conditioning.

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Timestamps

0:00 Revolutionizing Cancer Treatment Through Metabolism Optimization
5:00 Exploring Skeletal Muscle's Role in Cancer Prevention and Treatment
13:14 Lactate's Role in Cancer and Metabolic Disorders
18:21 Nanoparticles in Cancer Treatment and Funding Challenges
22:21 Understanding Zone 2 Training and Its Potential Health Benefits
25:52 Understanding Exercise Zones and Metabolic Fuel Sources
31:39 The Benefits of Zone Two Training for Longevity and Health
40:50 Rethinking Exercise Guidelines for Optimal Health
43:11 Exploring the Impact of Zone 2 Exercise on Cancer
50:41 Optimizing Exercise for Cancer Prevention and Longevity

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The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman