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The Neuro Experience

Zone 2 Training and Cancer Metabolism: The Science Behind Peak Metabolic Health | Dr Inigo San Millan

Feb 11, 2025
Dr. Inigo San Millan, a leading expert in metabolic health and exercise science, discusses the transformative role of lactate in both athletic performance and cancer metabolism. He emphasizes the benefits of Zone 2 training for boosting mitochondrial function and longevity. The conversation explores how skeletal muscle can aid in cancer prevention and the exciting potential of engineered nanoparticles in targeting cancer cells. San Millan also advocates for more rigorous physical activity guidelines to enhance health outcomes, especially for cancer patients.
58:44

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Quick takeaways

  • Skeletal muscle plays a protective role against cancer development, as its health and mass are linked to lower cancer rates.
  • Zone 2 training enhances mitochondrial function, promoting fat oxidation and metabolic efficiency crucial for cancer prevention and overall health.

Deep dives

The Role of Skeletal Muscle in Cancer Prevention

Skeletal muscle plays a significant role in cancer prevention, as elite athletes, who possess superior muscle health, may provide insights into optimal metabolic conditions that inhibit cancer development. Research indicates that cancer rates are lower in individuals with more skeletal muscle mass, suggesting a protective effect. Dr. Inigo Sanmilan emphasizes that while certain cancers exist, skeletal muscle itself does not seem to develop cancer, which opens avenues for understanding metabolism and cancer therapy. The hypothesis is that healthy muscle metabolism could offer clues for both preventing and treating cancer due to its unique interactions with various physiological mechanisms.

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