Dive into vascular Ehlers-Danlos syndrome. What is it? How does it present? Get clues to its diagnosis and learn more about collagen than you ever wanted to know.

• Intro 0:12
• In this episode 0:17
• Why vascular Ehlers-Danlos syndrome? 0:28
• Case study: Dr. Mories 2:20
• What can we learn about vascular Ehlers-Danlos syndrome? 05:02
• Collagen and elastin 05:57
• Collagen: horses and glue 07:07
• More about collagen 10:35
• Why is it a problem to miss a little bit of collagen? 14:14
• The problem in vascular Ehlers-Danlos syndrome 15:06
• The history of vascular EDS 15:41
• How is vascular Ehlers-Danlos syndrome diagnosed? 16:36
• A vascular Ehlers-Danlos syndrome diagnosis 22:33
• Mouse models 23:29
• Clinical and genetic features of vascular Ehlers-Danlos syndrome 24:39
• Question of vasculitis 25:55
• The skin: the most common symptom of vascular EDS 28:00
• Family history, de novo mutations and pregnancy 29:43
• Surgery or vascular intervention 31:39
• How do patients do in the long-term? 32:54
• Summary 34:00
• Preview of part 2 35:42
• Thanks 36:25

Disclosures: Brown reports no relevant financial disclosures.

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Pepin MG, et al. Genet Med. 2014;doi:10.1038/gim.2014.72.

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