Siim Land Podcast #458 The Forgotten Role of Creatine and Exercise in Depression - Nicholas Fabiano, MD
Jun 20, 2025
Dr. Nicholas Fabiano, a mental health expert and researcher, discusses the powerful impact of creatine and exercise on depression. He explains how creatine can enhance neurotransmitter function and potentially work in synergy with antidepressants. The conversation delves into the biological and psychological benefits of exercise, emphasizing its vital role in mood enhancement. Fabiano also addresses the correlation between dietary choices and mental health, advocating for a personalized approach to managing depression through both nutrition and physical activity.
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Exercise Boosts Neuroplasticity
- Exercise induces neuroplasticity, helping the brain unlearn negative associations common in depression and anxiety.
- This neuroplastic state also enhances therapy effectiveness by rewiring harmful thought patterns.
Creatine Supports Brain Energy
- Depression involves increased brain energy demand with impaired ATP production.
- Creatine supplements replenish brain energy rapidly, helping alleviate depression symptoms.
Creatine's Anti-Inflammatory Role
- Creatine may exert anti-inflammatory effects relevant to depressive disorders.
- Since some depression types are linked to inflammation, creatine offers promising adjunctive benefits.
