Emergency Medicine Cases Ep 184 Must Know Drug Interactions in Emergency Medicine
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Jun 27, 2023 AI Snips
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Loperamide Toxicity Case
- A 28-year-old man presented with shortness of breath and near syncope, abusing loperamide and taking sertraline.
- He developed torsades de pointes and required ICU admission, highlighting loperamide's potential cardiotoxicity.
Loperamide's Cardiotoxicity
- Loperamide, an opioid, can cause QT prolongation and sodium channel blockade at high doses.
- Combining it with other QT-prolonging drugs like sertraline can have synergistic cardiotoxic effects.
Consider Drug Interactions
- Always consider drug interactions, especially in complex cases.
- While often benign, drug interactions can cause severe consequences when they do occur.