

#382 Dr. Mike T Nelson - Metabolic Flexibility Masterclass, Efficiently Using Carbs and Fat As Fuel
Jul 17, 2025
Dr. Mike T. Nelson, a leading expert in nutrition and training, dives into the fascinating world of metabolic flexibility. He explains how our bodies can efficiently use carbs and fats as fuel, revealing the intricacies of insulin resistance and the impact of sleep on metabolic health. Listeners will learn about the challenges of extreme diets like the ketogenic plan and the emerging 'Sugar Diet.' Discover the surprising relationship between activity levels, caloric burn, and metabolic function, alongside practical tips to enhance insulin sensitivity!
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Metabolic Flexibility Basics
- Metabolic flexibility is your body's ability to efficiently use carbs and fats as fuel and switch between them.
- Optimizing flexibility can improve health, body composition, and exercise performance.
Fuel Choice by Activity Intensity
- Use carbs for high intensity and performance activities like lifting or sprints.
- Rely on fat for low intensity activities and improve fat burning to ease fat loss.
Ketogenic Diet Impairs Carb Metabolism
- Chronic ketogenic diets downregulate carbohydrate metabolism enzymes like PDH.
- This reduces high-end carbohydrate metabolism and performance by about 8-10%.