ZOE Science & Nutrition The brain-gut mystery: what’s really causing your IBS? with Dr. Will Bulsiewicz
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Apr 24, 2025 
Join Dr. Will Bulsiewicz, a board-certified gastroenterologist and bestselling author, as he unravels the mysteries of irritable bowel syndrome (IBS). He explains why IBS is notoriously difficult to diagnose and how modern lifestyles and stress amplify symptoms. Discover the crucial gut-brain connection and why women are disproportionately affected. Dr. Will shares practical strategies, from dietary changes to innovative treatments, offering hope and insights for those struggling with IBS and anyone curious about gut health.
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Gut Microbiome's Central Role
- IBS is a complex disorder with no single test or cure, involving a disturbed interaction between gut and brain.
- The gut microbiome acts as a key conductor in this gut-brain communication influencing IBS symptoms.
Jonathan's Gut Healing Journey
- Jonathan Wolf experienced gut issues after an infection and was misdiagnosed with IBS linked only to stress.
- His diet then was highly processed and hurting his gut, unlike the diverse approach that helped him later.
High Prevalence of Digestive Issues
- About 40% of people globally experience chronic digestive issues, but fewer strictly meet IBS criteria.
- IBS is among several functional GI disorders characterized by symptoms rather than testable diseases.
