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Breakpoints

#35 – Oral Beta-Lactams, Are We Serious?

Mar 19, 2021
01:02:05

Podcast summary created with Snipd AI

Quick takeaways

  • Oral beta-lactams, including cephalosporins, can be a suitable treatment option for respiratory infections like COPD exacerbations or uncomplicated cellulitis.
  • The use of oral beta-lactams in osteomyelitis and endocarditis requires careful patient selection and adherence to guidelines.

Deep dives

Cephalosporin Pearls for Oral Therapy

When it comes to first-generation cephalosporins, cephalexin is commonly used, but cephedroxil is an oral cephalosporin with great bioavailability that is often overlooked. It can be dosed twice daily and may be worth considering more often. Additionally, for automatic IV-to-PO protocols, some hospitals are converting cephradine to cephalexin for urinary tract infections if the organism is susceptible. This excludes bacteremia. For respiratory infections, such as COPD exacerbations or uncomplicated cellulitis, oral beta-lactams, including cephalosporins, can be a suitable treatment option.

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