Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition

The Biology of Health & Longevity | Top Expert Insights from 2025

Dec 28, 2025

Guest

Dr. Stacy Sims, an exercise physiologist, discusses female-specific training and the importance of adjusting workouts during perimenopause. Doug Evans, a plant-focused entrepreneur, highlights the benefits of sprouts and sheds light on the misconceptions surrounding seed oils. Dr. Iñigo San Millán explores mitochondrial health through Zone 2 training, emphasizing its role in fat oxidation. These experts reveal actionable insights on holistic health, nutrition, and the intelligent design of our bodies, making for a fascinating conversation.

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ADVICE

Short Sprints Twice Weekly

Do two weekly sprint-interval sessions of ≤30s all-out with 2–3min recovery to boost mitochondria and glucose uptake.
Pair short sprints with strength training to efficiently support muscle, bone, and metabolic health.

ADVICE

Combine Strength And Sprints

Do one compound heavy lift in a 30-minute session, then finish with a couple of 30s sprints for maximal time-efficiency.
If pressed for time, split short sprints and lifting across the day to still get both stimuli.

INSIGHT

Training Shapes Menopause Outcomes

Start perimenopause training habits early because strength and sprint work build resilience for postmenopause.
Maintaining fast-twitch fibres and lactate production supports brain metabolism and may protect cognition.

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As we wrap up another incredible year of Live Well Be Well, I found myself asking one simple question. What truly stayed with me?

In this conversation, I’m joined by world-leading voices who helped shape some of the most meaningful discussions of 2025, including:

Dr. Stacy Sims, exercise physiologist redefining how women should train, fuel, and recover

Dr. Andy Galpin, performance scientist translating elite physiology into everyday health

Doug Evans, longevity thinker exploring how nutrition and lifestyle shape long-term vitality

Dr. Iñigo San Millán, physiologist uncovering the role of mitochondria in metabolic health and endurance

Jason Van Blerk, founder of Human Garage, offering a new lens on fascia, movement, and healing

This episode is a reflection not only on science, but on perspective. Across these conversations, a shared message emerged. Our bodies are not machines to override. They are intelligent systems that respond to care, context, and consistency.From female specific physiology and metabolic flexibility to recovery, fascia, and longevity, these voices bring clarity to a crowded wellness space. Together, they remind us that sustainable health is built through understanding rather than optimisation alone.

Here’s What We Dive Into:- How female physiology changes the way women should train, fuel, and recover.

- Why performance science must move beyond one size fits all advice.

- What metabolic flexibility really means and why it matters beyond elite sport.

- How mitochondrial health underpins energy, endurance, and long term wellbeing.

- Why recovery is an active biological process, not simply rest.

- What fascia reveals about pain, movement, and whole body connection.

- How modern lifestyles disrupt our biology and what helps restore balance.

- Why longevity depends more on fundamentals than shortcuts.

Love,

Sarah Ann 💛

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This episode is sponsored by:NOWATCH: The compassionate health trackerConnecting body and mind with unique stress recovery insights so you can live fully today15% off with code LWBW15 at nowatch.com

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00:00:00 The question that shaped this year end reflection

00:04:18 Female physiology and outdated fitness narratives

00:09:42 Performance science beyond extremes

00:15:06 Metabolic flexibility explained simply

00:20:31 Mitochondria and sustainable energy

00:26:47 Recovery as a biological skill

00:32:10 Fascia, pain, and whole body communication

00:37:58 Longevity through fundamentals

00:43:21 What listening to the body really means

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