High Performance Longevity #232 NAD+, Energy & Longevity: How to Restore Cellular Power Naturally | Dr. Dan Pardi @Qualia
Oct 23, 2025
In this discussion, Dr. Dan Pardi, Chief Health Officer at Qualia Life Sciences and expert in cognitive neuroscience, shares insights on NAD+, a crucial coenzyme for cellular energy. He explains how NAD+ acts as a cellular battery, why its levels decline with age, and the role of sirtuins in aging and DNA repair. Dr. Pardi also covers dietary strategies to enhance NAD+ levels, including natural yeast-derived nutrients, and discusses the impact of inflammation on cellular health, making it clear that maintaining NAD+ is essential for longevity.
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NAD Acts Like A Cellular Rechargeable Battery
- NAD is a universal coenzyme that shuttles electrons like rechargeable batteries, powering virtually all cellular metabolism.
- NAD and its forms (NADH, NADP/NADPH) enable both energy transfer and biosynthetic repair processes across cells.
NAD Predates Life And Is Deeply Conserved
- NAD likely existed before life and enabled early redox chemistry that made life possible on Earth.
- This primordial role explains why NAD is conserved across species and central to cellular metabolism.
A Century Of Discovery Led To The NAD Renaissance
- NAD research progressed from fermentation discoveries to roles in redox and DNA repair across decades.
- Interest surged when aging biology and sirtuin/NAD links made it a geroscience focal point around the 2000s–2010s.
