How sirtuins consume NAD and affect aging

Dan explains sirtuin biology, their NAD-dependent activity across compartments, and their role in repair, inflammation, and stress resilience.

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Ever wonder why your energy fades faster as you age?

Dr. Dan Pardi of Qualia Life Sciences explains how NAD+ supports metabolism, DNA repair, & brain health, & how simple bioharmonizing habits can restore your cellular power naturally.

Meet our guest

Dr. Dan Pardi is the Chief Health Officer at Qualia Life Sciences, where he designs health-improvement journeys, guided protocols & education systems that simplify complex science for lasting results.

Formerly the founder & CEO of humanOS.me & Chief Health Architect at Restore Hyper Wellness, he’s led collaborations with top researchers, military units & wellness organizations.

With a PhD in Cognitive Neuroscience & a background in Exercise Physiology, Dr. Pardi empowers people & institutions to master healthspan, performance & resilience through science-backed systems.

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Key takeaways

NAD existed before life & kickstarted living processes
NAD+ is a universal coenzyme that transfers energy across all cells, keeping you alive & well
Enzymes act like machines while coenzymes (NAD+) serve as the tools they need to work
NAD+ sits at the center of all metabolic processes, regulating glucose, building, & breaking down substances
Mainstream interest in NAD+ surged after Dr. David Sinclair’s book Lifespan hit shelves around 2017
NAD+ levels drop every decade, leading to less energy & slower cellular repair with age
Sun exposure both helps & harms Too much damages DNA & drains NAD+ through increased repair demands
Chronic inflammation & DNA damage reduce NAD+ levels faster, causing energy loss & fatigue
Oral NAD+ precursors boost cellular energy more efficiently than IV NAD+ for daily health with fewer side effects
Good sleep, regular exercise, & healthy habits maintain NAD+ levels, slowing aging & improving performance