The sirtuin hype, setbacks, and balanced view

Dan recounts Sirtris, resveratrol research, pharma interest, and the consensus that sirtuins are important but not sole master regulators.

Play episode from 36:24

chevron_right

Transcript

chevron_right

Transcript

Episode notes

Ever wonder why your energy fades faster as you age?

Dr. Dan Pardi of Qualia Life Sciences explains how NAD+ supports metabolism, DNA repair, & brain health, & how simple bioharmonizing habits can restore your cellular power naturally.

Meet our guest

Dr. Dan Pardi is the Chief Health Officer at Qualia Life Sciences, where he designs health-improvement journeys, guided protocols & education systems that simplify complex science for lasting results.

Formerly the founder & CEO of humanOS.me & Chief Health Architect at Restore Hyper Wellness, he’s led collaborations with top researchers, military units & wellness organizations.

With a PhD in Cognitive Neuroscience & a background in Exercise Physiology, Dr. Pardi empowers people & institutions to master healthspan, performance & resilience through science-backed systems.

Thank you to our partners

Outliyr Biohacker’s Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear
Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more
Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world
FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus

Key takeaways

NAD existed before life & kickstarted living processes
NAD+ is a universal coenzyme that transfers energy across all cells, keeping you alive & well
Enzymes act like machines while coenzymes (NAD+) serve as the tools they need to work
NAD+ sits at the center of all metabolic processes, regulating glucose, building, & breaking down substances
Mainstream interest in NAD+ surged after Dr. David Sinclair’s book Lifespan hit shelves around 2017
NAD+ levels drop every decade, leading to less energy & slower cellular repair with age
Sun exposure both helps & harms Too much damages DNA & drains NAD+ through increased repair demands
Chronic inflammation & DNA damage reduce NAD+ levels faster, causing energy loss & fatigue
Oral NAD+ precursors boost cellular energy more efficiently than IV NAD+ for daily health with fewer side effects
Good sleep, regular exercise, & healthy habits maintain NAD+ levels, slowing aging & improving performance