Blood Cancer Talks

Episode 27. Management of PNH

Jul 31, 2023

01:03:29

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Episode notes

Introduction

2min

What Motivated You to Become Hash President?

3min

P&H Overlap: A Case Study

3min

The Problem With P&H Clone in a-Plastic Anemia

5min

The Role of Clonal Growth in PNH

4min

The Paradox of P and H

5min

How to Identify and Diagnose P&H

3min

How to Diagnosis PNAH

5min

The Overlap of Plastic Anemia and PNH

5min

10.

The Importance of PNH Clones in Bone Marrow Transplants

4min

11.

The Pro-Thrombotic Tendency in P&H

2min

12.

The Importance of Clone Size in P&H

3min

13.

The Role of Prophylactic Anticoagulation in Patients With P&H

2min

14.

How to Treat Intravascular Homolysis

6min

15.

Peg C2Cope Plan for CD55 and CD59

2min

16.

The Potential Side Effects of Complement Inhibitors

6min

17.

Factor B and Factor D Inhibitors: What You Need to Know

6min

In this episode, we delve into the diagnosis and management of Paroxysmal Nocturnal Hemoglobinuria (PNH) with Dr. Robert Brodsky.
Here are the shownotes for key papers we discussed in the episode:

How I treat PNH: https://pubmed.ncbi.nlm.nih.gov/33512400/
Alternative donor BMT with posttransplant cyclophosphamide as initial therapy for acquired severe aplastic anemia: https://pubmed.ncbi.nlm.nih.gov/37084383/
Pegcetacoplan versus eculizumab in PNH: a) https://pubmed.ncbi.nlm.nih.gov/33730455/ b) https://pubmed.ncbi.nlm.nih.gov/35349667/
Phase 2 study of danicopan (factor d inhibitor) in patients with paroxysmal nocturnal hemoglobinuria with an inadequate response to eculizumab: https://pubmed.ncbi.nlm.nih.gov/34314483/
Complement and prothrombotic state: https://pubmed.ncbi.nlm.nih.gov/34415298/