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#070 Dr. Eran Elinav on Microbiome Insights into Personalized Response to Diet, Obesity, and Leaky Gut

Feb 8, 2022

Dr. Eran Elinav, a leading immunologist at the Weizmann Institute of Science, discusses the fascinating world of the gut microbiome and its profound impact on health. He shares insights into how circadian rhythms affect microbial activity and metabolic health. The conversation dives into the significance of early exposure to environmental bacteria for childhood immunity and the role of diet personalization based on individual microbiome responses. Elinav also explores innovative treatments like bacteriophage therapy and the complex relationship between diet, obesity, and gut health.

01:56:44

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Episode guests

Eran Elinav

Highlights

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Episode notes

Time Restricted Eating Can Affect the Gut Microbiome

01:49

Genes vs. Environment in Shaping Microbiome

01:30

Invasive Micobiam Study

02:38

The Effects of Artificial Sweeteners

00:23

Intro

6min

Gut Bacteria and Circadian Rhythms

23min

The Benefits of Early Dirt Exposure on Immune Health

3min

The Microbiome: A Complex Relationship

17min

Unraveling Yo-Yo Obesity and the Gut Microbiome

22min

Understanding Microbiome Interventions

15min

Bacteriophages and the Microbiome Revolution

19min

The Role of Meal Timing in Personalized Nutrition and Dietary Intervention

3min

Revolutionizing Personalized Nutrition through Microbiome Insights

3min

10.

Exploring the Impact of Continuous Glucose Monitoring on Personal Health

2min

11.

Exploring Personalized Nutrition Through Microbiome Research

3min

Eran Elinav, MD, PhD, is a professor of immunology and principal investigator at the Weizmann Institute of Science in Tel Aviv, Israel, where he co-directs the Personalized Nutrition Project. Dr. Elinav is also a principal investigator at the German Cancer Research Center in Heidelberg, Germany. His research focuses on understanding the complex interactions between humans and the bacteria that reside in their gut and how these interactions shape human health and disease.

In this episode, Dr. Elinav and I discuss...

(00:00) Introduction to Dr. Eran Elinav
(06:38) Circadian rhythm of the microbiome
(17:17) Lessons from Hunter-gatherers
(24:44) Nurturing the microbiome in children
(35:16) Triglycerides and cholesterol
(38:58) Saturated fat
(40:25) Effect of artificial sweeteners on the microbiome
(56:10) What causes recurrent obesity
(58:17) Impact of caloric restriction
(59:26) Intestinal permeability (gut leakiness)
(01:19:54) Bacteriophage therapy and precision probiotics
(01:34:44) Bacterial role in TMAO risk
(01:40:33) Weight gain from smoking cessation
(01:41:53) Tips for diet personalization

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