The Genius Life 503: How to Prevent Alzheimer’s Before It Starts (Brain Health Hacks That Actually Work) | Louisa Nicola
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Aug 6, 2025 Louisa Nicola, a neurophysiologist and human performance expert, discusses strategies to prevent Alzheimer's disease and boost brain health. She highlights the critical role of estrogen for women, especially during menopause, and emphasizes the benefits of resistance training for cognitive function. The conversation dives into the significance of omega-3 fatty acids and the rising popularity of sardines as a health food. Nicola also addresses the risks of online supplement purchases and champions a balanced diet rich in natural foods to enhance cognitive health.
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Early Alzheimer's Pathophysiology
- Alzheimer's begins silently decades before symptoms, involving amyloid and tau proteins.
- Amyloid may protect neurons initially but harms synaptic communication if not cleared.
Alzheimer's Disease Complexity
- Alzheimer's disease is not mostly genetic, and many cases are not determined by known risk genes.
- Beta amyloid acts as a protective molecule linked to brain inflammation, not just a harmful agent.
Brain's Housekeeping System
- The glymphatic system clears amyloid and other debris from the brain during deep sleep.
- This brain 'housekeeping' is crucial for preventing amyloid buildup and cognitive decline.
