The Hunter Williams Podcast

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/👉Join The Fully Optimized Health Private Membership Group: https://www.fullyoptimizedhealth.com/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/Are you ready for the latest retatrutide news? In this video, I (Hunter Williams) dive deep into a brand new phase 2 study on retatrutide—Eli Lilly’s groundbreaking triple agonist peptide for fat loss and metabolic health. I break down the real-world body composition data, including fat loss, muscle loss, visceral fat reduction, and how retatrutide stacks up against other GLP-1 therapies like semaglutide and tirzepatide.I’ll walk you through the DEXA scan results, discuss the clinical trial design, highlight key numbers (including fat loss index, total lean mass loss, and cardiovascular risk improvements), and share why more is not always better with retatrutide dosing. If you want to know what’s truly happening at the cutting edge of metabolic health—don’t miss this video!Timestamps0:00 – Introduction & why today’s retatrutide news matters1:00 – Study background: Why body composition data is critical2:08 – What is retatrutide? The triple agonist mechanism explained3:07 – Retatrutide vs. other GLP-1s: The new study design4:25 – Clinical trial details (participants, dosing, DEXA scan protocol)6:24 – Key results: Total fat mass reduction at different doses7:40 – Surprising findings: Is 8mg the “sweet spot” for fat loss?8:35 – Total body weight loss vs. placebo and dulaglutide9:21 – How much muscle do you lose on retatrutide? Lean mass data10:13 – Visceral fat reduction: Why it matters for long-term health11:12 – Impact on trunk/leg ratio & cardiovascular risk markers12:08 – Fat loss index: Proportion of fat vs. muscle lost13:19 – Retatrutide vs. semaglutide and tirzepatide: Head-to-head data14:50 – Safety profile & common side effects15:31 – The role of glucagon receptor agonism & future of peptide therapies16:38 – Main takeaways: More is not always better with retatrutide17:41 – Big picture: What’s next for retatrutide and obesity treatment?18:44 – Final thoughts, feedback, and gratitude👇 Drop your thoughts and questions below. For more deep dives, subscribe and check out the links in the description—including the peptide cheat sheet and the full study!

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/👉Join The Fully Optimized Health Private Membership Group: https://www.fullyoptimizedhealth.com/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/Timestamps:0:00 - Intro to Pancragen: What It Is and Why It Matters1:36 - What Is Pancragen? Molecular Details and Origins2:59 - Mechanism of Action: DNA Binding and Epigenetic Modulation5:07 - Effects on Beta Cells and Insulin Production6:08 - Effects on Alpha and Acinar Cells: Digestion and Glucagon7:15 - Anti-Apoptotic and Anti-Aging Cellular Effects8:09 - Blood Glucose Regulation and Fasting Insulin9:48 - Melatonin, Sleep, and Insulin Sensitivity11:18 - Anti-Inflammatory and Immune Support in the Pancreas12:11 - Vascular Protection in Diabetic Models13:00 - Applications for Type 2 Diabetes13:28 - Exocrine Function and Digestive Health14:18 - Anti-Aging and Gerontology Uses15:00 - Clinical Use in Russia + Oral vs Injectable15:54 - Rodent Study: Blood Sugar and Vascular Benefits16:28 - Monkey Study: Blood Glucose, Insulin, and C-Peptide17:34 - Lasting Improvements from Short-Term Use18:07 - Cell Culture Study: Gene Expression in Young vs Old Cells19:40 - Apoptosis and Melatonin Interactions20:34 - Safety, Breakdown, and Excretion Pathways21:50 - Elderly Human Study: Improved Insulin Resistance22:50 - Chronic Pancreatitis Improvements & Protein Metabolism23:34 - Dosing Protocol: 2mg Daily for 30–60 Days24:09 - Final Thoughts: Pairing with GLP-1s & My Personal Use

Link to Study: https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1616693/fullGet My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/👉Join The Fully Optimized Health Private Membership Group: https://www.fullyoptimizedhealth.com/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/Timestamps:0:00 - Introduction & Why I’m Covering SLU-PP-3321:40 - What Is SLU-PP-332? Why It’s Important for Longevity and Fat Loss2:10 - Study Overview: How Researchers Tested SLU-PP-3323:40 - Aging, Muscle Decline, and Why Exercise Matters6:00 - Key Molecular Players in Muscle Metabolism (FNDC5, ERα, SIRT1, PGC1α)8:20 - How SLU-PP-332 Works (ERRα Activation, Mitochondria, Muscle Formation)10:57 - Clinical Results: Differences in Active vs. Inactive Subjects12:36 - Protein Expression and Effects of SLU-PP-332 on Muscle Samples13:38 - Quantitative Study Outcomes (Oxidative Stress, Antioxidant Capacity, Senescence)15:39 - How SLU-PP-332 Mimics Effects of Exercise at the Cellular Level16:50 - Implications for the Elderly and People Who Can’t Exercise17:45 - Takeaways: Muscle Preservation, Fat Loss, and Future of SLU-PP-332 Research18:50 - Final Thoughts, My Personal Experience & Community FeedbackIn this deep-dive, I review a new study where researchers tested SLU-PP-332 (Sloop) on human muscle biopsies from elderly women. Instead of giving the peptide orally, they treated the muscle samples directly—allowing for a clear look at SLU-PP-332’s cellular effects. The study found that Sloop could mimic the benefits of exercise at the molecular level, increase mitochondrial biogenesis, improve antioxidant capacity by 117%, reduce oxidative stress by almost 38%, and even upregulate proteins crucial for muscle growth and maintenance—especially in inactive or aging muscle.I break down the molecular mechanisms (FNDC5, SIRT1, PGC1α, ERRα) and how SLU-PP-332 helps reverse markers of muscle aging, senescence, and atrophy. If you want to know how to preserve muscle, burn fat, and possibly extend your healthspan—especially if you struggle to exercise due to injury or age—this video is packed with actionable insights.I wrap up with my personal thoughts, why I use Sloop, and encourage you to share your own experiences in the comments for the benefit of the community.If you found this valuable, please like, comment, and subscribe. And check the video description for the peptide cheat sheet and more resources.

Dive into the fascinating world of peptide therapies! Discover how low-dose nicotine can enhance autoimmune health and focus. Learn about stacking peptides for fat loss breakthroughs and the benefits of specific peptides for heart disease recovery. Explore the advantages of mitochondrial peptides in combating fatigue. Plus, get insights into testosterone and hormonal treatments for wellness. Tanning tips with melanotan 1 and personalized dietary approaches add to the vibrant discussion on health and wellness!

Dive into the fascinating world of hormone health, exploring the effects of testosterone on blood thickness and the importance of holistic wellness. Discover innovative supplements for liver and kidney health, alongside critical discussions about the challenges of modern medical education. Delve into female health with Human Growth Hormone, and investigate the benefits of injectable treatments for performance enhancement. Engage in lively debates about parenting in the digital age, dietary insights, and personal stories that connect health journeys with humor.

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/👉Join The Fully Optimized Health Private Membership Group: https://www.fullyoptimizedhealth.com/1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/Vilon Peptide: The Secret Weapon for Immune Balance, Longevity, and Recovery0:00 - Introduction & What is Vilon?0:40 - How Vilon Feels: My Personal Experience1:35 - Use Cases: Longevity, Pain, Autoimmune, and More2:32 - What is Vilon? Thymic Bioregulator Explained3:04 - History: Soviet Origins and Development4:37 - Unique Properties: Small Structure, Immune Regulation5:31 - Immune Modulation: How Vilon Restores Balance6:00 - Mechanisms: Calcium, T-Cells, Cytokines, and More7:05 - Epigenetic Rejuvenation: Turning Back the Clock8:23 - Pathways Activated by Vilon9:13 - Immune System Restoration: Data in Aging and Disease10:29 - Longevity Effects: Lifespan, Tumor Reduction, Activity11:22 - Anti-Cancer Properties12:21 - Tissue Regeneration, Recovery, and Healing13:22 - Inflammation Modulation: From Gut to Surgery14:20 - Improved Metabolic and Organ Function15:28 - Organ Specific Benefits: Heart, Kidneys, and More15:45 - Nootropic and Brain Health Potential16:22 - Safety Profile: Side Effects, Tolerance, and Risks18:20 - Dosing: Animal and Human Protocols19:55 - Cycling Protocols for Longevity21:18 - High Dose Protocols: What Science and Experience Show21:32 - Routes of Administration (SubQ, IM, Oral, Nasal)22:50 - Study Review: Tumor, Lifespan, Recovery, Immunity24:22 - Human Trials: Diabetes, Wound Healing, Immunity25:13 - Potency vs. Other Peptides25:32 - Synergistic Stacks: Epitalon, Thymalin, SS-31, and More27:53 - Conclusion: Summary and Who Should Try Vilon29:06 - Practical Results: Inflammation, Gut, Recovery29:32 - Use Cases: Health, Longevity, Recovery30:09 - Mission: Making Peptides Accessible for All⸻In this deep dive, I reveal everything you need to know about the vilon peptide—one of the most underappreciated and potent thymic bioregulators. Discover its Soviet research origins, molecular mechanisms, immune balancing, longevity effects, anti-cancer data, healing powers, nootropic potential, and protocols for real-world use. I break down published studies, my experience, and stacking strategies with other powerful peptides like Epitalon and SS-31. Whether you’re fighting chronic inflammation, seeking to reverse biological aging, or wanting optimal recovery and resilience, this video gives you the latest science and my personal tips for dosing, cycling, and maximizing results.

Dive into an innovative peptide protocol designed to tackle significant weight loss challenges. Discover how retatrutide can suppress appetite and enhance healthy weight management. Learn about the vital roles of peptides like MOTC and HGH in boosting metabolism while preserving muscle mass. The discussion emphasizes a structured approach to fat loss, highlighting the importance of diet, lifestyle changes, and community support for achieving your goals within six months. Get ready to transform your health!

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/👉Join The Fully Optimized Health Private Membership Group: https://www.fullyoptimizedhealth.com/start-here1 On 1 Coaching Application: https://hunterwilliamscoaching.carrd.co/Book A Call With Me: https://hunterwilliamscall.carrd.co/Supplement Sources: https://hunterwilliamssupplements.carrd.co/Amazon Storefront: https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DYSocials:Instagram: https://www.instagram.com/hunterwilliamscoaching/Podcast: https://hunterwilliamspodcast.buzzsprout.com/Video Topic Request: https://hunterwilliamsvideotopic.carrd.co/Curious about the pros, cons, and real-world protocols for using human growth hormone (HGH) and growth hormone peptides together? In this video, I share my personal experience, the science, and practical cycling strategies for optimizing results—whether your goal is fat loss, muscle growth, or longevity.Timestamps0:00 – Introduction & Why I’m Updating This Topic1:00 – My Core Belief: HGH Is the Gold Standard (But Peptides Have a Place)1:42 – What Are Growth Hormone Peptides? GHRPs vs GHRHs Explained2:20 – HGH vs Peptides: The Core Difference2:58 – Why Use HGH? My Personal Experience and When It’s Best3:53 – How Exogenous HGH Works (and the Pituitary Shutdown Question)4:53 – Peptide Types: GHRH vs GHRP (and Why It Matters)5:28 – The Science of Peptide Synergy: Why Combine Peptides?7:19 – What Happens When You Stack Peptides (CJC+Ipamorelin)8:02 – Key Benefits: Lean Muscle, Fat Loss, Recovery, and More9:04 – Fat Loss: How HGH and Peptides Each Work10:37 – Recovery, Sleep, Skin, and Cognitive Benefits12:11 – Metabolic and Cardiovascular Benefits13:01 – Comparing HGH and Peptides Head-to-Head14:33 – Risks: Side Effects of HGH vs Peptides15:58 – Accessibility, Cost, and Dosing Frequency16:56 – My Favorite Protocols: How I Cycle HGH and Peptides17:31 – How to Alternate and Combine for Maximum Effect18:19 – Pulsatile Therapy, Circadian Rhythm, and Optimizing Results19:11 – Example Yearly Cycle: How I Use HGH and Peptides Throughout the Year20:49 – Why You Need to Experiment for Yourself (Personalization is Key)22:02 – Final Thoughts, Gratitude, and How to Ask Me QuestionsWhat you’ll learn in this video: • The real science and mechanism behind HGH and growth hormone peptides • My honest protocol for stacking and cycling both for best results • When to use just peptides, just HGH, or both together • How to avoid side effects and get the best from your regimen • My seasonal “real-life” cycling strategy for year-round progressWant the full peptide cheat sheet and exclusive protocols? Check the link below. And join our Fully Optimized Health community to nerd out with 700+ other biohackers.Drop your questions in the comments—I read them all!

Learn about the transition from tirzepatide to retatrutide, focusing on their distinct mechanisms and how to optimize weight loss. Discover practical dosing strategies and tips for managing side effects. This insightful discussion highlights the benefits of retatrutide for metabolic health and offers a comprehensive guide for those considering the switch. Whether you're looking to enhance fat loss or stay updated on the latest peptide protocols, this conversation provides valuable insights.

Explore the intriguing link between metformin and estrogen management. Discover why blocking estrogen might not be the best approach for men on testosterone. Instead, learn how metformin could serve as a healthier alternative to traditional aromatase inhibitors. The discussion also dives into the role of visceral fat and insulin resistance in hormonal balance, shedding light on effective lifestyle changes to optimize health.