The Hunter Williams Podcast

GLOW and KLOW are Worthless?! | A Deep Dive Analysis on Peptide Stability

Jan 16, 2026
Dive into the hot topic of peptide stability as the host debunks the myth that Glow and Clo blends are ineffective. Discover the science behind copper coordination, pH stability, and why aggregation risks are minimal. Hear about the intricacies of co-lyophilization and why the pharmaceutical industry shies away from multi-API products. Get insights from a 21-day degradation test revealing only slight stability losses and learn best practices for usage. Overall, it's a fascinating exploration of peptide integrity, backed by research and experience.
Ask episode
AI Snips
Chapters
Transcript
Episode notes
INSIGHT

Blends Are Mechanistically Plausible

  • Hunter Williams argues Glow and Clo blends are mechanistically stable when properly manufactured and stored.
  • He says common instability claims lack plausible chemical drivers without extreme pH, strong chelators, or thiols.
ANECDOTE

Brother-In-Law Avoided Neck Fusion

  • Hunter describes his brother-in-law avoiding neck fusion after eight weeks of Glow injections.
  • He uses this case to illustrate observed clinical benefit from the blends.
INSIGHT

GHK-Cu Binding Is Strong

  • GHK binds copper with very high affinity and has low dissociation constants at physiological pH.
  • That strong binding makes copper dissociation unlikely in normal peptide formulations.
Get the Snipd Podcast app to discover more snips from this episode
Get the app