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Today’s episode is my updated deep dive on IGF-1 LR3, and I’m doing it for a very specific reason: this is a peptide I genuinely love using, but most people either don’t know it exists… or they only know it through the bodybuilding mythos that’s been floating around for years.
IGF-1 LR3 got popular in the research community because it was labeled as the “holy grail” that would supposedly turn you into a stage-winning bodybuilder overnight. I’m telling you right now — that’s not the use case, and if that’s the expectation, you’re going to be disappointed. What I am going to talk about is the real longevity optimization lane: strategic, disciplined, a few times per year — mostly around preserving and building muscle, improving body recomposition, and supporting healthspan as IGF-1 declines with age.
We’re going to break down what IGF-1 LR3 actually is (and how it’s different from other IGF options), the mechanisms that make it so interesting beyond “muscle building” — including some under-discussed mitochondrial and brain angles — and then we’ll talk practical use: timing, why I prefer post-workout, how to avoid the biggest mistake people make (hypoglycemia), and why this isn’t a “beginner peptide.”
I’ll also explain where IGF-1 LR3 fits in the bigger picture if you’re already doing TRT, GH peptides or HGH, and metabolic optimization. And as always — if you want the links, the resources, and the back catalog of my deleted YouTube content, make sure you’re on the email list. Check the description, and check out the Axion Collective — that’s my main mission in 2026: building the most ego-free, judgment-free place to learn this stuff with like-minded people.
Let’s get into it.
The Hunter Williams Podcast