The Hunter Williams Podcast Saturday Morning Coffee Talk 1/17/26
Jan 18, 2026
Jen Seeger, a doctorally trained nurse and biohacking expert, joins the discussion to unpack hormone optimization. They dive into the benefits of prioritizing testosterone before estradiol for women's health and address its effects on mood. Jen shares practical tips for approaching healthcare providers about hormone therapy, while exploring peptides like 5-Amino and their roles in performance. They also tackle fertility strategies, inflammation reduction with thymogen, and the implications of using GLP-1 for obesity management, rounding out a rich conversation on health and biohacking.
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Introduce Hormones One At A Time
- Introduce one hormone at a time so you can track effects and let the body adapt.
- Consider optimizing testosterone and progesterone before layering in estradiol for peri/postmenopausal women.
Estradiol Alone Can Backfire
- Raising estradiol without adequate testosterone can worsen mood and cause symptoms like anxiety or hot flashes.
- The body normally balances estradiol and testosterone, so artificially high estradiol can create emotional and physical issues.
Dosing Injectable 5‑Amino
- Start injectable 5‑Amino at ~1 mg subcutaneously and adjust upward if needed.
- Try IM for stronger performance effects and use before workouts for best results.
