The Hunter Williams Podcast Cardarine for Longevity and Performance | Revisiting GW-501516 in 2026
Jan 20, 2026
Explore the fascinating world of Cardarine, a compound touted as 'exercise in a pill.' Discover its origins as a PPARδ agonist and how it works to enhance endurance and fat metabolism. Delve into animal studies revealing impressive results in endurance and lipid profiles, along with concerns regarding cancer risks. Learn about dosing recommendations and the benefits of microdosing for longevity. Tune in for insights on integrating Cardarine with other peptides for optimal performance and wellbeing.
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PPARδ Reprograms Muscle And Metabolism
- GW501516 (Cardarine) is a potent PPARδ agonist that reprograms muscle to favor fat oxidation and endurance.
- It also acts systemically in liver and adipose tissue to improve lipid handling and reduce inflammation.
Exercise-Like Endurance Effects In Animals
- In animal studies Cardarine dramatically increased endurance by shifting muscle toward slow-twitch, oxidative fibers and boosting mitochondrial enzymes.
- Treated animals ran far greater distances and showed less fat accumulation despite similar food intake.
Short Human Trials Show Metabolic Gains
- Limited human trials showed meaningful lipid and metabolic benefits at doses up to 10 mg/day over short periods.
- Observed effects included higher HDL, lower triglycerides, reduced ApoB, less liver fat, and markers of improved fatty acid transport in muscle.