Night Science

Sir Isaac Newton reflects on his scientific methods and diverse interests in mathematics, physics, and alchemy. He discusses inspiration, regrets in alchemy, and the importance of empirical evidence. The episode features Prof. Michael Strevens from New York University as a medium. The podcast explores Newton's impact on experimental philosophy and his character, providing insights for budding scientists.

Bo Xia, a Junior Fellow at Harvard and Principal Investigator at the Broad Institute, shares his intriguing journey from suffering a tailbone injury to unlocking the mysteries of human evolution. He discusses the discovery of the TBXT gene mutation responsible for tail loss and its impact on bipedalism. Bo highlights the competitive nature of genes, likening non-coding regions to 'selfish genes.' The conversation also touches on the collaborative spirit of research, illustrating how curiosity can lead to groundbreaking insights into human anatomy and related medical conditions.

Todd Golub, Director of the Broad Institute of MIT and Harvard, is a leading figure in cancer research and advocates for bottom-up creativity in science. He highlights how true scientific breakthroughs evolve from organic, collaborative efforts rather than strict designs. Golub discusses the importance of hiring researchers willing to embrace change and the synergy between art and science. He emphasizes that flexibility and interdisciplinary collaboration are vital for fostering innovative discoveries, urging scientists to embrace unexpected results.

Sean Carroll is a world-renowned scientist, author, educator, and an Oscar-nominated film producer. Sean sees storytelling as the key to all he does. Similar to how musicians get inspiration by listening to other people’s music, Sean attributes his own creativity to his insatiable habit of reading about other people’s science – that’s how he “fertilizes his garden”. To tell a good story, he urges us to seek the emotions. But storytelling is not just for communication: in a research project, we also must develop a narrative, connecting the dots.For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .

Nigel Goldenfeld, a Chancellor's Distinguished Professor in Physics at UC San Diego, compares scientific research to jazz improvisation. He discusses how scientists, like musicians, must evolve from rigid structures to creative collaboration, encouraging students to embrace unconventional ideas. Goldenfeld emphasizes the joy of ‘playing off’ each other during discussions, and the importance of tackling unique problems. The conversation also touches on the dynamics of group sizes for effective brainstorming, revealing that innovation thrives where diverse thoughts can freely collide.

The podcast discusses the importance of talking to someone to generate new ideas. It emphasizes the value of sharing half-baked ideas, embracing collaboration and improvisation, and the benefits of conversation and collaboration in idea generation. It also explores the practice of mathematicians having discussions in elevators to eliminate obstacles and generate new ideas.

Rich White, Professor of cancer studies at Oxford University, talks about the process that led to a result being more interesting than the result itself. He thrives on working on common questions with scientists from different disciplines. Rich identifies new questions by finding connections between edge cases in research papers. The importance of friendship and chemistry in scientific collaboration is emphasized. The speakers discuss the significance of exploring edge cases and making connections in different fields, understanding different disciplines, and inspiring others to pursue a career in thinking.

Carolyn Bertozzi, Nobel Prize-winning chemist, discusses the unstructured process of science and how breakthroughs can come from unexpected places. She also highlights the challenges faced by newcomers in the field and emphasizes the importance of personal chemistry in running a successful lab. The podcast explores the distinction between day science and night science, the role of creativity in research, and the value of collaborations. It also discusses the frustrations and breakthroughs in tuberculosis study and the concept of the long game in science.

Join Stephen Quake, a Stanford professor and Head of Science at the Chan Zuckerberg Initiative, as he shares insights from his groundbreaking work in DNA sequencing. He discusses the surprising benefits of jetlag and the importance of generosity in scientific collaborations. Quake emphasizes the value of embracing mistakes in research, advocating for education that nurtures creativity and resilience. He also highlights how personal experiences shape scientific inquiry, encouraging future scientists to maintain faith in the unpredictable journey of discovery.

John Mattick, a Professor of RNA Biology at the University of New South Wales, challenges the notion of 'junk' DNA, arguing for its crucial regulatory roles. He reflects on how engaging in debates with his mother and aunts shaped his analytical skills. Mattick emphasizes the importance of publishing manifestos to boost research and advocates for questioning established scientific paradigms. He encourages students to embrace creativity by seeking out what doesn’t make sense, reminding us that intuition is vital in tackling complex genetic ideas.