48 | Carolyn Bertozzi and a long game called science
Dec 25, 2023
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Carolyn Bertozzi, Nobel Prize-winning chemist, discusses the unstructured process of science and how breakthroughs can come from unexpected places. She also highlights the challenges faced by newcomers in the field and emphasizes the importance of personal chemistry in running a successful lab. The podcast explores the distinction between day science and night science, the role of creativity in research, and the value of collaborations. It also discusses the frustrations and breakthroughs in tuberculosis study and the concept of the long game in science.
Chemistry plays a crucial role in team dynamics, highlighting the importance of a cohesive and harmonious lab environment.
Scientific progress often relies on building upon the work of previous generations, emphasizing the significance of collaboration and collective contributions over time.
Deep dives
The Importance of Chemistry in Band Dynamics
During her time as a keyboardist in a band, Carolyn Bertosi learned the crucial role chemistry plays in band dynamics. It became clear that different lead singers brought out different responses from the band, showcasing the importance of a cohesive and harmonious team. This understanding of chemistry has been brought into her lab where she emphasizes the significance of team dynamics when hiring new members.
The Night Science Approach
Carolyn Bertosi embraces the concept of night science, the process of hypothesis generating and making connections and discoveries. She finds that her scientific journey doesn't follow a structured plan but rather involves a balance between experimentation and contemplation. The desk science, which includes reading, planning, and thinking, often leads to unexpected breakthroughs, and sometimes ideas are sparked during everyday activities outside of the lab.
The Importance of Multidisciplinary Training
Carolyn Bertosi discusses the value of multidisciplinary training, drawing from her experience in the field of chemical biology. Initially, this kind of training was met with skepticism, with concerns about being a jack of all trades. However, the tables have turned, and those with multidisciplinary backgrounds are highly sought after in industry and academia. The ability to bridge fields and see connections between different areas of expertise has become an asset in advancing scientific knowledge.
The Long Game of Science and Collaborations
Carolyn Bertosi emphasizes the long game of science, noting that breakthroughs often come from building upon the work of previous generations. Scientific progress can take decades, and she provides a personal example where her research on tuberculosis built upon discoveries made a century ago. She highlights the importance of collaboration, sharing knowledge with others, and acknowledging the collective contributions of many scientists over time.
Carolyn Bertozzi is a Professor at Stanford University. In 2022, she was awarded the Nobel Prize in Chemistry. In this episode we talk about how the process of science is unstructured, so you don’t know when and where the next idea is going to come – sometimes even at the supermarket checkout line. For Carolyn, science is a long game, where one person’s negative result might be picked up a decade or a century later, leading to a new breakthrough. When a field is just being born, its new members may have a difficult time finding positions in academia and industry, as they are not experts in any traditional field. And Carolyn tells us how being in a band with Tom Morello, the guitarist of Rage Against The Machine, taught her about the personal chemistry required for running a successful lab.
This episode was supported by Research Theory (researchtheory.org) and the Independent Media Initiative (theimi.co). For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .
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