Eric Edmeades and Ben Grynol discuss the shift from prediabetic to postdiabetic, focusing on healthy glucose levels and insulin response. They talk about reversing type 2 diabetes, Wildfit program, and changing relationship with food. The podcast explores the makings of obesity epidemic, fuel sources, and consequences of type 2 diabetes.

Dr. Robert Lustig and Ben Grynol discuss the functions of glucose, the implications of reactive hypoglycemia, understanding glycemic index and load, how insulin drives fat storage, the damage caused by glucose spikes, effects of eating late before bed, healthy glucose levels, and the importance of managing insulin resistance for overall health.

Dr. Casey Means and Dr. Robert Lustig discuss the book 'Good Energy' focusing on using food as medicine to improve health, reducing ultra-processed foods, different types of exercise for mitochondria, rebranding healthcare, and children's nutritional needs through functional medicine.

Dr. Robert Lustig and Ben Grynol discuss the importance of metabolic health in the US, how to determine metabolic status, and fixing metabolism quickly. They highlight the impact of lifestyle habits on maintaining metabolic health and stress the significance of consistent habits. The conversation covers topics like the role of insulin in fat growth, using glucose as a proxy for fasting insulin, and the necessity of lifestyle changes for long-term metabolic health.

Dave Feldman, Dr. Nick Norwitz & Dr. Dominic D’Agostino discuss the lean mass hyper-responder phenotype, Oreo vs statin study, role of exercise, alarming LDL levels, gym hypothesis, and the need for further research on ketogenic diets and cholesterol impact on health.

Dr. Casey Means and Mike Haney discuss the book-writing process, seeking an agent, challenges in content clarity, collaboration, determining voice, and dedicated writing time. They emphasize health coaching for accountability and the magic of bringing joy to health conversations.

Dr. Rob Lustig and Dr. Dominic D’Agostino discuss insulin resistance, its impact on chronic diseases, the importance of monitoring insulin levels, and the role of insulin in weight management. They challenge traditional calorie theories, emphasize the need to manage insulin levels, and explore the effects of amino acids on metabolism.

Dr. Georgia Ede and Dr. Dominic D’Agostino discuss the connection between diet and brain health, the benefits of ketogenic diet for mental health, tailoring diets to prevent side effects, the link between gut health and mental health, and the importance of individualized nutrition in improving overall well-being.

Josh Clemente & Dr. Dominic D'Agostino discuss tracking macros for fat loss and muscle gain. Topics include prioritizing protein intake, benefits of tracking macros, roles of each macronutrient, concerns about excess protein and carbohydrates, and how tracking macros can improve health and fitness.

Dr. Richard Johnson and Dr. Rob Lustig discuss how fructose could be a driver of Alzheimer's disease. They explore fructose's impact on obesity, metabolic syndrome, and cognitive functions, suggesting a potential connection to other conditions. The podcast delves into new research on fructose inducing a foraging response in the brain and its inhibitory effects, raising the question of fructose's role in various health issues beyond Alzheimer's.