Drs. Karl and Spencer chat about their now defunct supplement company along with the ethics of big pharma direct to consumer marketing (including influencers).

The hosts debunk myths about pelvic floor health and discuss the importance of self-care. They explore the link between heavy weightlifting and pelvic floor dysfunction. The chapter covers evaluation and treatment methods for pelvic floor issues, including post-pregnancy and postpartum factors. They highlight the timeline for improvement and the role of neuromuscular control. Raising awareness of pelvic floor symptoms and providing resources for education and evaluation are also discussed.

Dr. Stuart Phillips, an expert on protein, discusses optimal protein intake for health and body composition. Topics include personal experiences with protein consumption, recommended protein intake, inkritin therapies and resistance training, muscle strength in relation to scans, and protein requirements for different populations.

Dr. Nicola Guess, an RD and PhD researcher from Oxford, dives into the world of continuous glucose monitors (CGMs) and their implications for those without type 2 diabetes. She discusses the nuances of glucose dynamics and the misconceptions surrounding glucose data interpretations. Nicola emphasizes the importance of understanding individual glucose responses, especially regarding diet and exercise. Plus, she highlights the potential mental health impacts of CGM usage, advocating for a more holistic approach to health rather than fixating solely on glucose levels.

Drs. Karl and Spencer discuss the new SELECT results that show a decrease in cardiovascular events in those taking Wegovy who have a history of cardiovascular disease. See trial below https://www.nejm.org/doi/full/10.1056/NEJMoa2307563

Discussion on the approval and effectiveness of tirzepatide for obesity, its availability and cost, differences compared to Mounjaro, and details about the Surmount 3 trial. Exploration of the limitations of endogenous GLP-1 and GIP production for obesity treatment. Dosing and indications of tirzepatide for glycemic control and weight reduction and the impact of intensive lifestyle therapy. Emphasis on the importance of lifestyle factors in weight loss, including weightlifting, muscle building, and regular strength training.

Dr. Kathleen Keller, researcher studying taste preferences and food choices in kids, discusses brain signaling in relation to obesity. The podcast explores childhood food preferences, brain changes and obesity through functional MRI, challenges and resilience in obesity, repeated exposure to develop food preferences, and the importance of helping people with obesity.

Drs. Karl and Spencer chat about some of the new tirzepatide studies including SURMOUNT-4 from the EASD

Dr. Bassin, a specialist in type 2 diabetes and physical activity, joins Drs. Karl and Spencer to discuss exercise and physical activity for type 2 diabetes. They explore the benefits of walking after meals, various activities to reduce the risk of type 2 diabetes, and the advantages of yoga for physical and mental health.

Drs. Karl and Spencer discuss how semaglutide impacts the heart with new trial data available. Learn how semaglutide may reduce risks of heart attacks and also how it impacts your quality of life if you have heart failure.