The Peter Attia Drive

Tommy Wood, an Assistant Professor at the University of Washington, specializes in brain injury and the impact of lifestyle on cognitive health. He discusses age-related cognitive decline and how lifestyle changes can mitigate risks. Drawing from his work with Formula 1 drivers, he emphasizes the connection between cognitive demands and brain function. Tommy also addresses dementia prevention through supplements and the significance of strength training in reducing risks. Furthermore, he provides insights into managing concussions and effective recovery strategies.

Dive into the fascinating world of the endocrine system, where thyroid hormones like T4 and T3 play crucial roles in health. Discover the intricacies of adrenal health, especially cortisol testing, and learn about the hormonal cycles affecting women, including fertility and menopause. Unearth the complexities of male sex hormones, particularly testosterone, and how it impacts overall wellness. Plus, get insights on hormone replacement therapy and its clinical applications for various deficiencies.

John Kastelein, a distinguished expert in lipoprotein metabolism and cardiovascular disease, discusses familial hypercholesterolemia (FH) and its genetic underpinnings. He explores innovative therapeutic options that could transform heart disease prevention, detailing the history and future of CETP inhibitors. Kastelein also delves into the APOE gene's significant role in both Alzheimer's and cardiovascular health. His insights emphasize the potential for targeted interventions, sparking optimism for high-risk patients in the near future.

Discover the intriguing world of cold therapy, where methods like ice baths and cryotherapy are examined for their benefits and potential downsides. Explore how cold exposure can impact muscle soreness, activate brown fat, and even boost mood. Dive into discussions about its possible drawbacks on muscle growth and longevity. Plus, enjoy a thrilling sidetrack into the excitement of the upcoming Formula 1 season, analyzing team dynamics and standout drivers. Cold therapy just got a lot cooler!

JoAnn Manson, a prestigious endocrinologist and epidemiologist, unravels the complexities surrounding hormone replacement therapy (HRT) and its controversial link to breast cancer. She highlights misinterpretations from the Women’s Health Initiative that skewed public perception and discusses the nuanced risks and benefits of HRT. JoAnn also examines the role of estrogen in breast cancer risk, advocating for personalized treatment approaches. With insights into the importance of individualized assessments, she aims to reshape how physicians approach HRT in practice.

Rhonda Patrick, Ph.D., is a scientist specializing in aging, cancer, and nutrition. In this engaging discussion, she dives into Alzheimer’s disease, revealing intriguing links to type 2 diabetes and the blood-brain barrier. Rhonda also addresses the impact of exercise on brain health and cancer risk, shedding light on the often-overlooked dangers of alcohol consumption. Additionally, she shares her evolving views on protein intake and fasting, emphasizing their roles in optimizing health and longevity.

In this conversation, Robert Sapolsky, a renowned Stanford professor and stress expert, delves into the intricate effects of stress on our health. He discusses how social rank and personality influence our stress responses, and shares fascinating insights from his time studying baboons in Kenya. Sapolsky reveals the brain's reactions under stress and the phenomenon of epigenetic imprinting, showing how stress can shape our children. Additionally, he examines the modern impact of socioeconomic status and technology on mental health and suggests practical stress management techniques.

This AMA dives deep into brain health, unraveling the complexities of Alzheimer's disease diagnosis and the significance of blood-based biomarkers. Discover how APOE gene variants alter your risk and explore strategies for prevention. Beyond exercise, Peter reveals surprising factors such as nutrition, lipid management, and even oral health that impact cognitive function. Learn about the intricacies of diagnosing neurodegeneration and the role of lifestyle choices in managing risks. It’s an enlightening talk full of actionable insights!

Andy Galpin, a Professor of Kinesiology, returns to share his expert insights on training for longevity. He discusses the training practices of powerlifters, CrossFit athletes, and sprinters to optimize fitness over time. Key topics include the role of exercise load, the importance of proper movement patterns, and training to failure for better outcomes. Andy offers a practical training plan tailored for longevity and emphasizes injury prevention techniques, highlighting the significance of balancing volume and intensity in workouts.

Join Andrew Huberman, a Stanford neurobiology professor and host of the Huberman Lab podcast, as he delves into the intricacies of the brain. He illuminates how the prefrontal cortex influences decision-making and creativity, while sharing personal stories of resilience and the value of therapy. Andrew discusses the significance of vision as a 'superpower' and critiques scientific literacy in society, advocating for better communication in research. His journey from self-doubt to academic success serves as an inspiration, highlighting mentorship's role in personal growth.