The Peter Attia Drive

Bill Gifford, co-author of 'Outlive: The Science and Art of Longevity,' joins Peter to share insights from the book's six-year writing journey. They discuss the evolution of the book, key themes of longevity and health, and the importance of making science accessible. Gifford reveals the creative process behind the book cover design and the challenges of translating complex ideas for readers. They also explore exciting advancements in cancer treatment and the future of personalized medicine, all while reflecting on their personal experiences throughout the project.

Dr. Ethan Weiss, a preventative cardiologist and entrepreneur-in-residence at Third Rock Ventures, delves into the intricacies of cardiovascular health. He compares diagnostic imaging tools like CAC and CTA in assessing ASCVD risk. Discussing the impact of blood pressure management, he emphasizes the importance of proper measurement and the need for personalized treatment strategies. Weiss also highlights the significance of metabolic health, fat distribution, and the limitations of current understandings, advocating for a proactive approach to cardiovascular disease.

Nick Stenson, co-host and health expert, dives into the intricate world of GLP-1 agonists like semaglutide and tirzepatide, discussing their effectiveness and potential side effects for weight loss. They also explore the rising interest in metformin as a longevity drug, addressing its applications beyond diabetes management. The conversation humorously touches on branding changes in weight loss medications, raising ethical questions about their use among non-overweight individuals. This engaging discussion offers a deep look at the future of these transformative therapies.

Lewis Howes, a New York Times best-selling author and motivational speaker, opens up about his early traumatic experiences, including his brother's incarceration and childhood abuse. He discusses how these challenges shaped his journey to success yet left him feeling unfulfilled. Howes emphasizes the importance of vulnerability, healing, and the benefits of therapy. He believes that trauma can catalyze growth if faced with courage, and shares insights on finding inner peace and living a meaningful life through resilience and support.

Siddhartha Mukherjee, an oncologist and Pulitzer Prize-winning author, dives deep into the fascinating world of cells and gene therapy. He discusses his latest book, emphasizing the transition from single-celled to multicellular organisms and its impact on medicine. The conversation explores cutting-edge advancements like CRISPR and CAR T-cell therapy while addressing ethical dilemmas in gene editing. Mukherjee also reflects on mental health, the challenges of medical science, and the storytelling intricacies of writing about complex topics.

In this discussion, Anthony Hipolito, a seasoned sheriff’s deputy with 24 years in law enforcement, dives deep into the fentanyl crisis. He highlights the alarming rise in accidental overdoses among the youth, sharing harrowing personal stories. Anthony explains how counterfeit drugs are laced with fentanyl and the challenges this poses for law enforcement. He emphasizes the importance of community awareness and provides crucial advice for parents to protect their children from this deadly epidemic. A compelling call to action for everyone to stay informed!

Explore the fascinating personal journey of body composition over 12 years, scrutinized through DEXA scans and blood tests. Discover how varying dietary approaches like ketosis and fasting affected muscle mass and visceral fat. Uncover the science behind fat storage with engaging analogies and metrics. Gain insights on the importance of tracking health metrics over time to understand personal health trends better. Finally, dive into the contrasting effects of protein intake across different diets on body composition.

Ric Elias, founder of Red Ventures and host of "Three Things with Ric Elias," shares transformative insights shaped by his near-death experience on Flight 1549. He emphasizes valuing time and the importance of intentional living for a rich life. Discussion includes evolving relationships with children, the significance of friendships, and lessons learned from parenting. He highlights the role of struggle in growth and the impact of nurturing meaningful connections. Elias also reflects on his philanthropic efforts and the importance of contributing to society.

Dan Rader, a Professor at the Perelman School of Medicine, dives into the complexities of high-density lipoproteins (HDLs) and their surprising relationship with cardiovascular disease. He emphasizes that high HDL cholesterol does not always mean low disease risk and discusses the importance of HDL functionality over mere quantity. Rader also explores the role of HDLs in reverse cholesterol transport, their link to neurodegenerative diseases, and the latest research that could change how we approach cardiovascular health. It's a deep dive into lipid metabolism that challenges common misconceptions.

Andy Galpin, a Kinesiology Professor at California State University, dives deep into the science of muscle. He breaks down muscle anatomy, the differences between strength, power, and hypertrophy, and their cellular implications. Galpin emphasizes the importance of protein for muscle synthesis and shares insights on muscle fiber types and their role in fitness. He even designs personalized strength programs for beginners, highlighting strategies for functional longevity. Whether you're an untrained individual or a seasoned athlete, this conversation is packed with valuable information!