The Stem Cell Podcast

Dr. Malin Parmar, an Associate Professor at Lund University, pioneers research on stem cell therapies for Parkinson's disease. She discusses her groundbreaking paper published in Cell Stem Cell, which has drawn significant media attention. The conversation delves into innovative strategies like in vivo reprogramming to transform glial cells into dopamine neurons for treatment. Parmar emphasizes collaboration in research and highlights the challenges and successes within the field, providing fascinating insights into the potential future of Parkinson's therapies.

Dr. Christina Lilliehook, Senior Editor at Cell Stem Cell, shares her journey in scientific editing and reveals the behind-the-scenes process of handling manuscripts. She discusses intriguing topics like a unique brain surgery that cured a man’s fear of spiders and sheds light on the complex development of penises in evolutionary biology. Dr. Lilliehook also dives into the challenges of peer review, the need for broad reading, and the importance of maintaining research integrity in the ever-evolving landscape of scientific publishing.

In this conversation with Dr. Harold Varmus, a Nobel Prize-winning scientist and director of the National Cancer Institute, they explore his groundbreaking contributions to cancer research and the challenges of securing NIH funding. The discussion highlights inspiring breakthroughs in cell transplantation for paralyzed patients and Gene therapy for genetic diseases. They also touch on the impact of diet on aging and the need for a supportive environment for young researchers. Humor weaves through critiques of scientific authorship, making it a compelling listen.

Dr. Ginger Campbell, a physician and the engaging host of the Brain Science Podcast, dives into fascinating concepts in neuroscience. She discusses near-death experiences and the implications of recent studies on brain function and memory. The conversation touches on innovative research in diabetes management and the intriguing relationship between sleep and cancer treatments. Plus, there's a humorous rant on the latest iPhone size, blending science with everyday life. Campbell's insights bridge complex topics with accessibility, making it a captivating listen!

Karen Weintraub, a freelance science writer known for her engaging pieces in major publications, shares insights from her recent New York Times article on stem cell research. She discusses groundbreaking advancements, the role of UM171 in therapy, and the challenges of funding and regulation in the field. The conversation also highlights the importance of public education to counter misconceptions about stem cell tourism. With a humorous touch, they wrap up discussing the quirks of automatic car windows, bringing levity to the serious topic.

Dr. Valentina Fossati, a prominent researcher at the New York Stem Cell Foundation, discusses her innovative work with iPSCs to generate oligodendrocytes for multiple sclerosis treatment. She delves into the complexities of MS, highlighting the significance of myelin and recent breakthroughs in regenerating myelin in models, like the shiverer mouse. The conversation balances scientific advancements with personal anecdotes, including her experiences as a new parent, blending the challenges of academia with life at home while advocating for thoughtful public health policies.

Dr. Austin Smith, a leading researcher in stem cell biology at the University of Cambridge, discusses the intricacies of pluripotency. He shares his insights on the essential components of the pluripotency network and the challenges of modeling these systems. The conversation explores the significance of the gene Nanog in embryonic stem cells, along with implications for regenerative medicine. Smith also delves into the fascinating roles of inhibitors like GSK3 in stem cell differentiation and the evolving landscape of scientific integrity.

Dr. Paul Knoepfler, an Associate Professor at UC Davis and a stem cell blogging expert, discusses the STAP cell controversy and the impact of Dr. Yoshiki Sasai's tragic death. The conversation delves into the complexities of scientific publishing and recent unethical practices, including retracted papers. Knoepfler also highlights breakthroughs in gene therapy, the emotional toll of scientific misconduct, and the importance of mental health awareness in the research community. This engaging dialogue combines serious issues with lighter, insightful moments.

Dr. Marco Seandel, a researcher from Weill Cornell Medical College, discusses his groundbreaking work on spermatogonial stem cells and how they reveal mutations in aged male sperm. He dives into the implications of paternal age on genetic disorders, such as Apert syndrome. The conversation is rich with insights on stem cell behavior and the balance of mutations in sperm development. Alongside humor, they touch on the challenges of collecting tissue samples and the inequities faced by researchers in academia, making for an engaging exploration of science.

Dr. Daylon James, an assistant professor at Weill Cornell Medical College and expert in stem cell biology, shares insights from his groundbreaking research on utilizing the vascular niche to transform endothelial cells into blood stem cells. The conversation dives into the significance of this niche in stem cell differentiation and its potential clinical applications. They also reflect on alarming disease outbreaks and fascinating studies about genetic similarities among friends, adding a layer of humor and depth to the serious scientific discussions.