The Stem Cell Podcast

Karen Weintraub, a freelance science writer known for her engaging pieces in major publications, shares insights from her recent New York Times article on stem cell research. She discusses groundbreaking advancements, the role of UM171 in therapy, and the challenges of funding and regulation in the field. The conversation also highlights the importance of public education to counter misconceptions about stem cell tourism. With a humorous touch, they wrap up discussing the quirks of automatic car windows, bringing levity to the serious topic.

Dr. Valentina Fossati, a prominent researcher at the New York Stem Cell Foundation, discusses her innovative work with iPSCs to generate oligodendrocytes for multiple sclerosis treatment. She delves into the complexities of MS, highlighting the significance of myelin and recent breakthroughs in regenerating myelin in models, like the shiverer mouse. The conversation balances scientific advancements with personal anecdotes, including her experiences as a new parent, blending the challenges of academia with life at home while advocating for thoughtful public health policies.

Dr. Austin Smith, a leading researcher in stem cell biology at the University of Cambridge, discusses the intricacies of pluripotency. He shares his insights on the essential components of the pluripotency network and the challenges of modeling these systems. The conversation explores the significance of the gene Nanog in embryonic stem cells, along with implications for regenerative medicine. Smith also delves into the fascinating roles of inhibitors like GSK3 in stem cell differentiation and the evolving landscape of scientific integrity.

Dr. Paul Knoepfler, an Associate Professor at UC Davis and a stem cell blogging expert, discusses the STAP cell controversy and the impact of Dr. Yoshiki Sasai's tragic death. The conversation delves into the complexities of scientific publishing and recent unethical practices, including retracted papers. Knoepfler also highlights breakthroughs in gene therapy, the emotional toll of scientific misconduct, and the importance of mental health awareness in the research community. This engaging dialogue combines serious issues with lighter, insightful moments.

Dr. Marco Seandel, a researcher from Weill Cornell Medical College, discusses his groundbreaking work on spermatogonial stem cells and how they reveal mutations in aged male sperm. He dives into the implications of paternal age on genetic disorders, such as Apert syndrome. The conversation is rich with insights on stem cell behavior and the balance of mutations in sperm development. Alongside humor, they touch on the challenges of collecting tissue samples and the inequities faced by researchers in academia, making for an engaging exploration of science.

Dr. Daylon James, an assistant professor at Weill Cornell Medical College and expert in stem cell biology, shares insights from his groundbreaking research on utilizing the vascular niche to transform endothelial cells into blood stem cells. The conversation dives into the significance of this niche in stem cell differentiation and its potential clinical applications. They also reflect on alarming disease outbreaks and fascinating studies about genetic similarities among friends, adding a layer of humor and depth to the serious scientific discussions.

Dr. Paul Tesar, an assistant professor at Case Western Reserve University, shares his insights on pluripotent stem cells and enhancer activity. He discusses groundbreaking research, including how stem cell transplants can reverse sickle cell anemia and the role of gut bacteria in transplant success. Tesar also elaborates on the distinctions between naive and primed stem cells, crucial for understanding pluripotency. With a humorous take on life outside the lab, he highlights the balance needed for a fulfilling scientific career.

Guest: This is a special episode consisting of over 75 minutes of live interviews. Last week The Stem Cell Podcast attended the International Society for Stem Cell Research meeting and pulled people aside to get their take on the meeting and stem cell research. We compiled all the interviews into one show for you to enjoy. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

Dr. Dieter Egli, a senior research fellow at the New York Stem Cell Foundation, dives into the fascinating world of somatic cell nuclear transfer (SCNT) and its application in generating embryonic stem cell lines. He shares insights from his groundbreaking research on creating therapeutic cells for diabetes. The conversation also navigates the ethical challenges of egg donation for research and public perceptions surrounding SCNT. Egli's journey highlights both the promising advancements and the complexities inherent in the evolving landscape of stem cell science.

Dive into the fascinating world of stem cell research! Discover the largest sperm ever found, and learn why some stem cells aren't making hearts. Innovative heart-on-a-chip technology steals the spotlight, while researchers unveil a new element on the periodic table. Delve into the intriguing realm of iPSCs from schizophrenia patients. And don’t miss the humorous rant about bathroom air fresheners that wraps up this lively discussion!