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The Stem Cell Podcast

Ep. 24: Sperm Stem Cells Featuring Dr. Marco Seandel

Aug 4, 2014
Dr. Marco Seandel, a researcher from Weill Cornell Medical College, discusses his groundbreaking work on spermatogonial stem cells and how they reveal mutations in aged male sperm. He dives into the implications of paternal age on genetic disorders, such as Apert syndrome. The conversation is rich with insights on stem cell behavior and the balance of mutations in sperm development. Alongside humor, they touch on the challenges of collecting tissue samples and the inequities faced by researchers in academia, making for an engaging exploration of science.
01:07:29

Podcast summary created with Snipd AI

Quick takeaways

  • Dr. Marco Seandel's research reveals that paternal age influences genetic mutations in sperm stem cells, affecting offspring health.
  • The episode explores how maternal experiences can shape offspring behavior and genetic programming through olfactory cues.

Deep dives

Understanding Sperm Stem Cells

The episode features a discussion about sperm stem cells, specifically spermatogonial stem cells, and their significance in understanding paternal age and its implications on offspring health. Dr. Marco Sandel from Weill Cornell is highlighted for his research on these stem cells, emphasizing how their behavior can be influenced by environmental factors. His recent paper describes the relationship between paternal age-associated mutations and the fitness of sperm stem cells, suggesting that older fathers may pass on certain genetic mutations that affect their children. This topic diverges from typical discussions surrounding stem cells, making it an intriguing focus for the episode.

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