
The Joe Cohen Show
Unlock the secrets of your DNA and optimize your health with The Joe Cohen Show. Join Joe, biohacker and founder of SelfDecode, as he interviews world-class health experts and shares cutting-edge research and strategies for biohacking your body and brain. From functional medicine tips and supplement recommendations to longevity and performance optimization, each episode is packed with insights to help you achieve your health goals. Whether you're interested in genetics, biohacking, alternative health, or simply improving your overall wellness, this podcast has something for you. Subscribe now!
Latest episodes

16 snips
Apr 28, 2023 • 48min
How To Get Rid Of Your Food Sensitivities And Eat Anything You Want | Joe's Regimen
Do you ever feel like you're walking on a tightrope, unsure of what foods might trigger an unwanted reaction? Well, you're not alone.
Food sensitivities are more common than ever, and they can cause a whole host of issues ranging from digestive discomfort to brain fog.
After years of research and experimentation, and with the help of SelfDecode, Joe found what he think is a break through in reversing food sensitivities.
Now, he can eat things that he never thought possible a few years ago.
So he’s decided to share his journey and discoveries with you in this episode.
He dives deep into the world of food sensitivities, sharing some life-changing insights that equip you with the tools you need to overcome your own food sensitivities.
Some highlights of what you'll discover in this must-listen episode:
The mechanics behind food sensitivities and how they affect your body
Joes tried-and-tested top 5 hacks for improving food sensitivities (featuring some surprising nutrients you might not have considered!)
The magic of butyrates and how they can transform your relationship with food
The connection between tryptophan, ApoB, and your ability to enjoy a wider range of foods
Check out SelfDecode
Join Joe’s online community
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13 snips
Apr 21, 2023 • 1h 20min
Understanding Test Results, Nutrient Deficiencies, and Genetics w/ Chris Masterjohn & Tommy Wood
How important is it for you to test and track your lab markers? Are some tests more important than others? Are functional lab tests useless, or is it just the way that companies are interpreting the data that renders it useless?
In this eye-opening episode, we brought on Dr. Chris Masterjohn and Dr. Tommy Wood to dive deep into understanding the complexities of test results, vitamin and mineral deficiencies, and genetic predispositions.
Chris and Tommy use their years of expertise and tremendous depths of knowledge in the health space to discuss the issues with alternative health tests and the best ways to utilize your DNA results.
They also discuss the effects of deficiencies on essential nutrients like zinc and how you can take control of your well-being by identifying unique deficiencies about your own body.
Chris Masterjohn served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. In the fall of 2016, he made the decision to leave academia and pursue independent research, consulting, working on information products, collaborating on information and technology products, and producing tons of free content to help people gain better health.
Dr. Tommy Wood is an MD with a Ph.D. in physiology and neuroscience. He has coached world-class athletes and is currently an Assistant Professor of Pediatrics and Neuroscience at the University of Washington.
- Find Dr. Tommy Wood on Instagram
- Find Chris on Instagram
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok
Timestamps:
(0:00) - Intro
(9:58) - Repeatability in testing
(18:28) - Validity of urine hormone testing
(31:00) - Chris’ thoughts on organic acids tests
(39:03) - Validity of organic acids tests
(43:52) - Fungal & yeast tests
(47:11) - Going over relevancy of some markers
(54:25) - Polygenic Risk Scoring
(1:00:47) - Nutritional Markers
(1:05:20) - Neurotransmitter Markers
(1:07:10) - Stool IgA Tests
(1:12:10) - Ion Amino Acids Panel
(1:16:51) - Summarizing functional lab tests

Apr 14, 2023 • 57min
Best of The Joe Cohen Show: Top 10 Moments of Season 2
To celebrate the end of Season 2, we’ve gathered the top 10 moments of The Joe Cohen Show and compiled them into a single podcast episode!
These moments were voted on by Joe, employees of SelfDecode, and listeners of The Joe Cohen Show.
It includes clips filled with valuable knowledge on different health topics and actionable takeaways that you can implement in your daily life.
Full The Joe Cohen Show Episode links:
Stacy Sims
Dominik Nischwitz
Richard Miller
Molly Maloof
Chris Masterjohn
Alex Leaf
Jeffrey Gladden
Carrie Jones
Vince Giuliano
Tommy Wood
Timestamps:
(0:00) - Intro
(0:18) - Stacy Sims
(7:38) - Dominik Nischwitz
(13:50) - Richard Miller
(19:08) - Molly Maloof
(26:58) - Chris Masterjohn
(30:09) - Alex Leaf
(33:41) - Jeffrey Gladden
(42:04) - Carrie Jones
(47:45) - Vince Giuliano
(51:24) - Tommy Wood
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok

26 snips
Apr 7, 2023 • 1h 9min
How To Increase Your VO2 Max, Master Your Metabolism, and Improve Your Lifespan with Jeffrey Gladden
Longevity is a concoction of many different things - VO2 max, HRV, telomere length, blood pressure, mTOR and AMPK, and so much more. Optimizing and improving your lifespan requires a balanced focus on all of these through lifestyle, diet, and supplement implementations.
Dr. Jeffrey Gladden - a Board certified interventional cardiologist and the founder of Gladden Longevity - is the guest of today's episode!
We explore the different strategies that claim to improve longevity and dive deep into the science behind specific exercises, supplements, and drugs that improve lifespan.
Jeffrey talks about the ways to master your metabolism by utilizing the economy of balance concept, discusses all the different ‘biological ages’ that can be used to interpret our health, and gives his tip on the best way to increase VO2 max.
Dr. Jeffrey Gladden is a Board certified interventional cardiologist and the founder of Gladden Longevity, Human Performance & Longevity Optimization. He did his undergraduate work at Wheaton College and earned his Doctor of Medicine degree with Honors from Temple University in 1982. He has specialized in many areas of cardiology, including interventional, diagnostic, preventative, and programmatic.
- Find Dr. Jeffrey Gladden at https://gladdenlongevity.com/
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok

6 snips
Mar 31, 2023 • 1h 3min
Health Analysis Series #02 | How To Discover The Best Diet & Supplements For Your Body with Briana Theroux
In our Health Analysis Series, Joe Cohen, expert biohacker and founder of SelfDecode, brings on a guest, and together they utilize the power of DNA and labs to assess, discuss, and recommend ways to further optimize their health.
Our guest today is Briana Theroux, a health professional certified by the Institute for the Psychology of Eating who has over a decade of experience biohacking her health.
In episode 2 of this 2 part series, Joe and Briana analyze her DNA results on SelfDecode, as well as her current and past lab markers.
They then discuss Briana’s current supplement stack, going in-depth on why each supplement is chosen and how it impacts her health.
Finally, they discuss ways that they can further optimize her health based on her genetic predispositions and lab markers - giving you the perfect outline on how you should approach your health!
This is the final episode of our Health Analysis Series.
- Find Briana on Instagram @liftheavybreatheeasy
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok

16 snips
Mar 24, 2023 • 59min
Health Analysis Series #01 | How To Navigate Your Health History, DNA, and Labs with Briana Theroux
In our Health Analysis Series, Joe Cohen, expert biohacker and founder of SelfDecode, brings on a guest, and together they utilize the power of DNA and labs to assess, discuss, and recommend ways to further optimize their health.
Our guest today is Briana Theroux, a health professional certified by the Institute for the Psychology of Eating who has over a decade of experience biohacking her health.
In episode 1 of this 2 part series, Briana goes over her health history, discusses some of the game-changing supplements and lifestyle changes she has done to overcome her health issues, and dives deep into some tips and tricks for biohacking as a woman.
This episode provides the foundation for the next episode, where Joe and Briana look at genetic predispositions and lab levels to brainstorm the next steps to optimal health.
- Find Briana on Instagram @liftheavybreatheeasy
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok

34 snips
Mar 19, 2023 • 1h 30min
What is your Biological Age?: The Best Tests and Strategies for Improving Your Health With Alex Leaf
Biological age is a critical indicator of our overall health and wellness. It's a measure of how well our body functions compared to others of the same chronological age.
But are all biological age tests the same? Are some more accurate indicators than other?
In this episode, Alex Leaf and I discuss the lifestyle factors that contribute to biological aging, such as diet, exercise, and stress management, and how we can make changes to improve our health and wellbeing.
We also talk about body image and its connection to mental health, and Alex shares his thoughts on Agmatine as well as his top 10 supplements.
Alex Leaf, M.S., holds a master’s degree in nutrition from Bastyr University and has been writing about the science of nutrition, health, and fitness for over a decade. Currently, Alex is a content creator and research writer alongside Ari Whitten at The Energy Blueprint. Formerly, Alex was a senior researcher at Examine.com and teaching assistant for the University of Western States' Human Nutrition and Functional Medicine masters program.
- Find Alex at www.alexleaf.com
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok

12 snips
Mar 10, 2023 • 47min
The Science of Sex-Specific Nutrition and Biohacking with Stacy Sims
Optimal nutrition is different from person to person, and even moreso from sex to sex. Men and women have many physiological differences that can truly change how to approach your health and fitness.
Are cold plunges good for men and women? What about saunas?
Dr. Stacy Sims - a forward-thinking international exercise physiologist and nutrition scientist - is the guest of todays episode, and we explore the physiological differences between male and female bodies and reveal how you can optimize your nutrition and training based on your unique needs.
We dive deep into specific vitamins and minerals, the difference in heat retention and how that affects health, and we discuss whether some biohacking methods - like cold plunges and saunas - are more optimal for one sex.
Stacy Sims has directed research programs at Stanford, AUT University, and the University of Waikato, focusing on female athlete health and performance and pushing the dogma to improve research on all women. Her contributions to the international research environment and the sports nutrition industry has established a new niche in sports nutrition; and established her reputation as the expert in sex differences in training, nutrition, and health
- Find Stacy on Instagram @drstacysims
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok

32 snips
Mar 3, 2023 • 1h 16min
The Ultimate Cold Prevention Protocol: Strengthening The Immune System with Chris Masterjohn
What are some steps that you can take to boost your immune system so that you can stop getting sick? What if you just started feeling some symptoms, are there specific supplements that will stop the sickness dead in its tracks?
Dr. Chris Masterjohn is back on the podcast to outline his Ultimate Cold Prevention Protocol!
In this episode, Chris and Joe go through all of Chris’ prevention protocol - starting with what to do to strengthen your immune system, to your action plan when you first experience the “suspicous sneeze”, to what different vitamins and minerals you should focus on when you’ve been infected.
Chris also discusses the importance of understanding scientific studies (it’s more than just looking at charts), the difference between focusing on deficiencies vs. optimization, and his thoughts on alternative health tests like organic acids and dutch tests.
Chris Masterjohn served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. In the fall of 2016, he made the decision to leave academia and pursue independent research, consulting, working on information products, collaborating on information and technology products, and producing tons of free content to help people gain better health.
- Find Chris on Instagram
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok
Timestamps:
(0:00) - Introduction
(1:00) - Chris’ thoughts on functional tests
(23:52) - Deficiency vs. Optimization
(29:30) - The immune system
(35:34) - The cold prevention protocol
(41:58) - The importance of understanding studies
(44:53) - Explaining Vitamin D
(48:59) - Continuing the cold prevention protocol
(56:07) - Nutrients for immunity
(1:07) - Glutathione

5 snips
Feb 25, 2023 • 1h 1min
Dr. Carrie Jones: How To Optimize Your Hormone Health For Mental Health & Energy
What supplements should I take to improve my hormones? Is there an optimal balance of estrogen and progesterone? Is prolactin an important hormone for men?
Hormones are an extremely important part of optimizing your health, but the majority of people have no idea just how much of an impact they have on… well, everything.
An estimated 30% of women experience hormone imbalances, which can cause mental health issues, weight issues, fertility, and much more.
That is an absolutely insane number!
So, I brought on Dr. Carrie Jones for this podcast to discuss all things hormone health and the growing studies that are helping put the spotlight on this important health area.
In this episode, Carrie shares the best thing you can do to optimize your hormones (in her words: it’s not that sexy), and we dive into detail on the relationship between estrogen, progesterone, prolactin, cortisol, and more. We also discuss how these are important hormones to keep track of for men.
- Find Dr. Carrie Jones on Instagram @dr.carriejones
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok
Timestamps:
(0:00) - Introduction
(1:31) - The difference between men and women
(3:16) - How hormone cycle effects training
(9:00) - Immune system and estrogen
(12:41) - Estrogen and sleep
(21:06) - Blood tests for hormones
(30:31) - Cortisol, stress, and hormones
(37:14) - Dopamine and prolactin
(46:53) - How to optimize your hormones
(51:30) - The best way to check your labs