
The Joe Cohen Show
Unlock the secrets of your DNA and optimize your health with The Joe Cohen Show. Join Joe, biohacker and founder of SelfDecode, as he interviews world-class health experts and shares cutting-edge research and strategies for biohacking your body and brain. From functional medicine tips and supplement recommendations to longevity and performance optimization, each episode is packed with insights to help you achieve your health goals. Whether you're interested in genetics, biohacking, alternative health, or simply improving your overall wellness, this podcast has something for you. Subscribe now!
Latest episodes

32 snips
Feb 18, 2023 • 1h 19min
Dr. Dome: How Oral Hygiene Effects Your Overall Wellness & Tips to Improve Oral Health
How important is oral health to your overall health? What are you really doing when you remove your wisdom teeth? Turns out, bad oral hygiene is linked to a lot of chronic diseases, like heart disease, metabolic issues, depression and anxiety, and so much more.
So how can you optimize your oral health? Dr. Dominik Nischwitz is on today’s episode to give you practical strategies that you can implement to improve your dental health and, through that, your overall health!
In this episode, Dr. Nischwitz discusses the importance of maintaining optimal health in the mouth and highlights the key nutrients that you need to keep your teeth and gums in the best shape possible.
He also shares tips to help with bad breath, whether you really need to floss, and if mouthwash is good or bad for you.
And finally, he reveals his three superhuman oral healthcare strategies to keep your mouth healthy.
Dr. Dominik Nischwitz is a dentist and naturopath, a world specialist in biological dentistry and ceramic implants and the current Vice-President of the International Society of Metal-free Implantology (ISMI). A pioneer in the field of holistic dentistry, Dr. Nischwitz regularly gives lectures around the world and has recently published his first book “IT´S ALL IN YOUR MOUTH" at Chelsea Green.
- Find Dr. Dominik Nischwitz on Instagram @drdome1
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok
Timestamps:
(0:00) - Introduction
(1:35) - The importance of oral hygiene
(15:52) - Improving teeth for the next generation
(18:12) - Important nutrients for good dental health
(26:25) - Dr. Dome’s Health Journey
(30:15) - Optimizing your mood using genetics
(34:40) - Circling back to dental health
(37:23) - How important is flossing?
(43:30) - Are mouthwashes good or bad?
(44:34) - The three superhuman oral healthcare strategies
(47:03) - The epidemic of bad breath and tongue diagnosis
(51:56) - 5 tips to help with bad breath
(57:22) - Dr. Dome’s thoughts on Niacin
(1:03:56) - The effects of antibiotics
(1:06:53) - The issues with cavitation - the silent inflammation
(1:10:26) - Thoughts on fluoride and dentist teeth cleaning

Feb 10, 2023 • 55min
Kris Gethin: Balance Your Training & Rest For Improved Longevity | Episode 17
It’s hard to slow down when you’re dopamine-dominant. Being highly motivated, fast-paced, and competitive has many benefits, but how can you slow down when it starts negatively impacting your health? Kris Gethin is on the podcast today to answer that, and much more!
In this episode, Kris and Joe discuss their thoughts on stem cell therapy, how to choose what supplements to add and remove for optimal fitness, and how Kris uses biohacking to balance his training with his focus on living a long and healthy life.
Kris also gives us an inside look at his daily routine and what he focuses on to optimize his diet and nutrition, which has resulted in him achieving a glycan age of 26 at the current chronological age of 48!
Kris Gethin is the co-owner of KAGED supplements, co-owner of the Kris Gethin Gyms, owner of Kris Gethin coaching and a hybrid athlete. He is the former editor in chief of bbcom, former editor at large of FLEX and came 2nd in Natural World bodybuilding championships in 2006.
- Find Kris Gethin on Instagram @krisgethin
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok
Timestamps:
(0:00) - Introduction
(2:56) - Kris’ Daily Routine
(10:42) - How Kris chooses his supplements
(15:24) - HRV and training
(21:18) - The neurochemistry behind overtraining and mood
(26:13) - Kris labs and supplements
(31:34) - Stem cells
(33:50) - Longevity and bodybuilding
(42:36) - How to improve glycan age
(45:43) - Th1 vs Th2 and megadosing supplements

16 snips
Feb 3, 2023 • 2h 5min
Chris Masterjohn: The Best Ways To Optimize Your Diet & Nutrition | Episode 16
As more people start focusing on their health, personalized nutrition is growing.
But it’s important to make sure that you understand what personalized diets entail, and how you can take the right steps to build the best nutrition plan for you. The best person to help you get started? Dr. Chris Masterjohn, who earned his PhD in Nutritional Sciences in 2012 and has been deeply entrenched in the research for 20+ years!
In this episode, Chris Masterjohn and Joe discuss issues with the RDA (Recommended Dietary Allowance), the differences in how they tackle health issues that come their way, and Chris outlines the steps he takes to discover the best supplements that improve his overall health!
Chris talks about how his battle with mold toxicity, how he solved a twitching problem, and his current experiment with a supplement that he thinks will be game changing for his health.
Chris Masterjohn served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. In the fall of 2016, he made the decision to leave academia and pursue independent research, consulting, working on information products, collaborating on information and technology products, and producing tons of free content to help people gain better health.
- Find Chris on Instagram
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok

36 snips
Jan 27, 2023 • 1h 40min
Molly Maloof: Optimize Mitochondrial Health To Boost Energy, Immunity & Stress Response | Episode 15
How important is mitochondrial function in increasing energy? Is intermittent fasting different for men and women? Is metabolic health being overlooked in the USA? In this episode, Dr. Molly Maloof and Joe discuss how important it is to focus on your mitochondrial health, and Molly gives her TOP suggestions to condition your mitochondria for optimal energy and health!
Molly talks about the epidemic that is metabolic diseases, and discusses the best way to structure your exercise schedule as a woman.
They also discuss the significance of continuous glucose monitors, what it means to have good lab levels, and specific biohacks to improve HRV.
Dr. Molly Maloof’s book THE SPARK FACTOR: The Secret To Supercharging Energy, Becoming Resilient, and Feeling Better Than Ever is on sale January 31st!
As a physician and Stanford lecturer, Dr. Molly Maloof has spent her career providing personalized medicine services to high-performing technology executives, billionaire investors, Silicon Valley entrepreneurs, and Academy Award-winning actors.
- Preorder Molly’s book: “The Spark Factor”
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok
Timestamps:
(0:00) - Introduction
(3:38) - Molly's daily routine & sleep schedule
(13:14) - Molly's supplement stack
(16:52) - Controversy surrounding IV NADs
(21:08) - Optimizing mitochondrial health
(29:51) - Oxytocin & human connection
(38:19) - Intermittent Fasting
(47:45) - CGMs and Hba1c
(1:01:14) - Optimizing exercise based on the menstrual cycle
(1:13:06) - What does it mean to have good lab levels?
(1:19:24) - The epidemic of metabolic diseases
(1:23:39) - Thoughts on psychedelics
(1:26:32) - Thoughts on Ketamine
(1:32:38) - Organic acids testing
(1:36:02) - Does Molly take Nootropics?

7 snips
Jan 20, 2023 • 1h 2min
Vince Giuliano: Tips To Improve Life Expectancy From A 93 Year Old | Episode 14
The longevity revolution is upon us, as more and more studies are being done to discover ways to increase lifespan. One of the strongest advocates of this revolution? Vince Giuliano, living a healthy and active life at the young age of 93!
In this episode, Vince Giuliano and Joe discuss how he’s made it into his 90s in tiptop shape, how he tackles health issues that come his way, and what he would have done differently if he can travel back in time.
Vince talks about how he got his HRV levels to outperform young and healthy athletes, and shares some of his favorite supplements - specifically one that he has been taking for nearly 40 years!
Vince also talks about non-supplemental ways that you can implement in your life to improve your health and increase your longevity.
Vince Giuliano was a university professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and COO of Mirror Systems, a software company, and an international Internet consultant. In various ways, he contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s, and is now engaged in doing the same for The Longevity Revolution. He has published over 200 books and papers as well as over 430 substantive entries in his blog.
- Find Vince Giuliano’s work at agingsciences.com
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok
Timestamps:
(0:00) - Introduction
(4:29) - When did Vince start his longevity journey?
(5:33) - Vince’s supplement journey
(18:08) - What Vince would do differently
(22:40) - Thoughts on Rapamycin
(31:27) - HRV & Heart Rate
(33:00) - Near infrared devices
(36:48) - More on Vince’s Supplement
(45:04) - Vince’s Top 5 Supplements

Jan 13, 2023 • 40min
Richard Miller: The Science Behind Longevity & How To Increase Lifespan | Episode 13
How far along is the science of longevity, and are there already proven methods that can increase your lifespan? In this episode, Richard Miller and Joe discuss the massive strides that are happening in the longevity space, and Richard shares the six compounds that have very promising research backing their benefit in improving life expectancy!
Richard talks about the problem with certain scientific studies and gives his thoughts on the controversial calorie restriction & longevity debate.
They talk about all kinds of drugs, including rapamycin, acarbose, reservatrol, and more, and discuss the one OTC supplement that has positive effects on lifespan!
Richard Miler is a Professor of Pathology at the University of Michigan, and Director of the Michigan Glenn Center on Aging. He got his MD and PhD at Yale, did postdoctoral work at Harvard and Sloan-Kettering, and was on the faculty at Boston University until his move to Michigan in 1990.
- Find Dr. Richard Miller’s work at www.richmillerlab.com
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok

23 snips
Jan 6, 2023 • 1h 4min
Tommy Wood: Are Alternative Health Tests Worth It? | Episode 12
Joe and Dr. Tommy Wood go over the most popular alternative health tests to tell you which ones are worth it and which ones are not.
Joe and Tommy discuss microbiome tests, organic acid tests, heavy metal tests, and so much more! Plus, find out the one occasion the Dutch test is helpful according to Dr. Tommy.
Tommy also shares the difference between IgE vs IgG food sensitivity tests and which one you should stay away from. They discuss whether vitamins & minerals tests are reliable, and tell you the problem with the RDA.
Find out what Tommy thinks about DNA tests, and why you shouldn’t try a health intervention based on a single SNP. Plus, Joe and Tommy discuss what’s the best approach when it comes to using genetic testing for health (spoiler: It’s polygenic risk scoring).
Dr. Tommy Wood is an MD with a Ph.D. in physiology and neuroscience. He has coached world-class athletes and is currently an Assistant Professor of Pediatrics and Neuroscience at the University of Washington.
- Find Dr. Tommy Wood on Instagram
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok

8 snips
Dec 16, 2022 • 19min
Joe's Regimen Part 3: Improve Mood With These Supplements | Episode 11
Find out Joe’s final 9 best supplements to improve mood! In this episode, Joe concludes his mood regimen of 18 supplements. Discover which supplements he’s been taking for years, and which two he’s thinking of removing from his regimen and why.
Joe talks all about betaine, vitamin B12, L-theanine, and more, and shares how he analyzes his personal health data (including family history, lifestyle, and predispositions) to decide which supplements to take and their dosages.
Joe also talks about why he cares about kidney health, and why you should too (spoiler: 90% of people who have kidney disease don’t know they have it). Plus, find out which mood supplement can surprisingly help with gray hair!
Listen to Parts 1 and 2 to discover 9 more supplements that are part of Joe’s mood regimen!
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok

12 snips
Dec 9, 2022 • 15min
Joe's Regimen Part 2: Best Mood Supplements Explained | Episode 10
What does a biohacker and a chef have in common? It may surprise you! In this episode, Joe continues to go through the supplements in his mood toolkit. He discusses 6 of his favorite supplements for mood, their mechanisms of actions, and effects. Plus, find out which supplement Joe would take if he couldn’t take 5-HTP.
He explains why finding out he had a zinc deficiency was a game-changer for his health and mood, the benefits of a zinc supplement, and what you need to look out for to see if you need more of this essential nutrient.
Learn more about the pros and cons of methylfolate, how to know how much you should take, and the surprising effects it has on fasting.
Joe also talks about one of the biggest mistakes he did in the beginning of his health journey, and why he’s commited to doing research and experiments with all supplements in his regimen.
Learn all about rhodiola, lithium orotate, and more!
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok

11 snips
Dec 2, 2022 • 22min
Joe's Regimen Part 1: Best Supplements For Mood | Episode 09
Find out what’s in Joe’s mood toolkit! Joe Cohen has been doing health experiments on himself for over 20 years, and he’s finally sharing all his knowledge with you.
In this episode, Joe walks you through lifestyle changes and 3 of his favorite supplements for mood: 5-HTP, thiamine, and resistant starch & butyrate. He discusses his megadosing experiments, dosages, and his problem with the RDA.
He explains why he takes each supplement, the mechanisms of action of these supplements, and the effects they have on his mood. Plus, discover the one problem Joe has with resistant starch.
Find out how Joe determines if he’s deficient in a nutrient, and the importance of learning your genetic predispositions and tracking your labs when building your regimen.
Learn all about Joe’s favorite mood stabilizer supplements!
- Check out SelfDecode
- Join Joe’s online community
- Follow Joe on Instagram & TikTok