The Joe Cohen Show

Have you heard of scientific wellness? In this episode, Nathan Price and Joe discuss whether the conventional approach of using pharmaceuticals to treat chronic diseases is effective, or if a preventative approach to complex conditions such as cardiovascular disease and Alzheimer’s is the best choice. Nathan explains how genes can help predict the success of lifestyle-based interventions and talks about the accuracy of polygenic risk scores vs single variants for disease prediction, and how genetics can be used in healthcare. Nathan and Joe also talk about nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), DHEA, and other supplements. Plus, Nathan explains the controversy of choline, carnitine, and TMAO, and if you should be worried. Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. He was named one of the 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine and was appointed to the Board on Life Sciences of the National Academies of Sciences, Engineering, and Medicine. - Preorder The Age of Scientific Wellness - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Should you be scared of psychedelics? In this episode, Tim Gray and Joe talk about how to get more REM and deep sleep, and Tim discusses his experience with methylene blue. They talk about the pros and cons of alcohol and their experience with different psychedelics. Tim shares his experience with conventional medicine, the top things he’s trying to optimize in his health and his strategies for kidney health, gut health, and more. He talks about how he used to track 35 biomarkers every day, and which ones he still continues to monitor. They discuss methylation, the MTHFR gene & SNPs, and how genetics and your environment can affect your overall health and how you respond to supplements. Tim Gray is the UK’s leading biohacker and the founder of the popular Health Optimisation Summit, The Biohacker London Meetup group, and London’s first private Hyperbaric Oxygen Clinic. He is dedicated health optimizing biohacker, a psychology specialist, entrepreneur, and global speaker. - Check out the Health Optimisation Summit (Use code SELFDECODE for 10% off your ticket) - Find Tim on Instagram - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Are supplements a waste of time and money? In this episode, Shawn Wells and Joe discuss whether taking supplements every day is bad for your health, and Joe shares the one time a supplement caused his liver enzymes to spike (it’s not what you’d expect!). Shawn talks about the problem with certain supplement companies and lets you in on important things to look out for when choosing a supplement. They talk about all kinds of supplements, including lipoic acid, dihydroberberine, paraxanthine, ergothioneine, NAD, and more, discussing their effects, dosages, and how they work in the body. Shawn and Joe also discuss the importance of optimal mitochondria function and why you should pay attention to it, and Shawn shares his ultimate mitochondrial supplement stack. Shawn Wells, MPH, LDN, RD, CISSN, FISSN, is the world’s leading nutrition biochemist and an expert on health optimization. He’s formulated over 700 supplements, foods, and beverages, and is the author of The Energy Formula. - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram & TikTok

Do supplements work the same for everyone? In this episode, Lucas Aoun shares his favorite supplements to improve cognitive function and focus, and he and Joe dig deep into how these compounds work in the body, discussing the research, dosages, and what to look out for. They discuss dopamine and the mechanisms behind dopamine supplements and share their different experiences experimenting with supplements. Plus, listen to the benefits of increasing dopamine levels steadily vs taking supplements that cause a spike. Lucas and Joe also talk about how to optimize testosterone levels, what causes low testosterone, and Lucas shares one surprising hack to increase your testosterone levels. Plus, find out one health hack Joe coins as “bromeopathy”. Lucas Aoun is the founder of Ergogenic Health and Australia's leading biohacker & men's health expert. This interview is not intended as medical advice. - Find Lucas on YouTube - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram

Low carb? Keto? Low fat? Fasting? In this episode, Katie Wells and Joe talk about her experience with dieting, some of the benefits she gets from intermittent fasting, and they discuss the controversial topic of cholesterol (spoiler: lower is not necessarily better). Katie shares some of her favorite health hacks, and they talk about how genetics can influence a person’s health and how to use this information to live optimally. They also discuss which and how to track labs, the importance of optimal vs normal ranges, and what Katie does to hack her sleep & mood. Katie Wells is the founder and CEO of wellnessmama.com and wellnesse.com. A mom of 6, she took her health into her own hands and started researching to find the answers to her health struggles. She has written over 1,500 blog posts, 3 books, and was named one of the most influential people in health and wellness. This interview is not intended as medical advice. - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram Timestamps: (0:00) - Introduction (1:04) - How Katie got into health (3:53) - The Personalized Health Podcast? (4:57) - Shifting of health goals (6:44) - Katie’s current health goals (8:14) - Joe shares his health journey (9:04) - What labs to track for anti-aging? (10:32) - Alcohol and saturated fats affect on health (12:31) - Katie Wells thoughts on LDL cholesterol (13:24) - Over-dieting and under nourishing (16:52) - Unsullied by paid sponsors (17:18) - Megadosing and metabolic flexibility (18:45) - Katies daily supplement intake & fasting (20:01) - The mental and spiritual benefits of a long fast (22:15) - Joe’s experience with fasting (23:42) - What supplements does Katie take now? (24:39) - Pregnenolone dosages & benefits (25:40) - Nootropic stack for focus (26:37) - Tips to improve sleep from Katie (28:45) - Katie’s most successful health “experiments” (30:09) - The importance of protein in your diet (31:40) - The last time Katie changed her mind about a health topic (32:42) - The best health hack Katie wished she found earlier (34:52) - Katie’s top hacks to optimize mood (36:36) - The difference between normal and optimal lab ranges (37:45) - How using SelfDecode can help optimize your lab levels (38:58) - The most interesting DNA discovery (41:10) - Katie’s expectations on her life span (43:15) - Characteristics that make you successful

Is high cholesterol really bad for you? In this episode, Joe and Siim Land discuss what causes high cholesterol, which biomarkers to track for longevity, and the biggest mistake people make when trying to lose weight. Siim shares one surprising mineral that can help lower cholesterol and talks about how intermittent fasting helps his mental & physical performance. Then, Siim and Joe discuss a top supplement for longevity and healthspan. Siim Land is a renowned public speaker and expert in biohacking, health optimization, and overall performance optimization. He is also the author of Metabolic Autophagy and The Immunity Fix with Dr. James Dinicolantonio. This interview is not intended as medical advice. - Check out SelfDecode - Join Joe’s online community - Follow Joe on Instagram Timestamps: (0:00) - Introduction (0:41) - Why Siim Got Into Biohacking (2:35) - What markers should you measure for longevity? (8:28) - Taking blood tests every year to track improvements (10:40) - The top supplement to improve longevity (13:21) - Unsullied by paid sponsors (13:47) - Cholesterol in the biohacking world (14:49) - Intermittent fasting, fats, and lowering cholesterol (17:30) - Zinc and Copper ratio (18:53) - Does lower T3 contribute to high cholesterol? (20:03) - One supplement with high evidence of increasing lifespan (21:00) - What Siim tracks on a regular basis (23:09) - Siim’s HRV numbers (24:20) - How Siim improves mental performance (26:51) - How Siim improves physical performance (30:35) - The biggest mistake people make with fat loss (35:21) - Genetics affect on portion control in diets (37:06) - How often is Siim physically active per day? (38:31) - How you process carbs differently based on your body composition (41:00) - Sleephacking tips from Siim Land (46:20) - Improving your immunity

Kiwi as a biohack for sleep? Bet you didn’t know that one! In this episode, Joe and Teemu Arina talk all about biohacking your sleep, low & high HRV ranges, why heart rate variability is important for your overall health, and discuss some of Teemu’s favorite biohacks for the body & brain. Teemu tells Joe why he got into biohacking, his secret to handling stress, and what he thinks is the best approach to optimizing his mental and physical performance. He also gives you a glimpse of what his supplement stack looks like and lets you in on one of his favorite supplements. Teemu Arina is a thriving speaker and the creator and organizer of the Biohacker Summit. He’s also the author of the Biohacker's Handbook: Upgrade Yourself and Unleash Your Inner Potential. This interview is not intended as medical advice. - Join Joe at the Biohacker Summit (Use code SELFDECODE10 for 10% off) - Check out SelfDecode - Follow Joe on Instagram Timestamps: (0:00) - Introduction (1:42) - How Teemu got into biohacking (7:43) - Optimizing the physical to improve the mental (10:10) - How to improve your creativity (13:03) - Personalizing your biohacking tools (21:18) - Unsullied by paid sponsors (21:45) - What is HRV and how Teemu increase his HRV (26:49) - What are Joe’s strategies for improving HRV (32:54) - The strength of the mind and negative effects of measuring (34:44) -  How the environment affects your sleep quality (36:38) - The best biohacks for sleep (41:00) - Melatonin’s effect on the body (42:51) - What supplements does Teemu take every day? (45:41) - Discount code for Biohacker Summit

Are EMFs harmful? Should you wear sunscreen? In this episode, Joe and Dr. Joseph Mercola discuss these and other controversial topics within the health industry. Dive deep into the importance of sun exposure (it’s not just vitamin D), vegetable oils, and learn valuable insights to hack your diet. Dr. Mercola shares his secret for better vitamin D levels, discusses the problems with linoleic acid and which foods to avoid, and talks about the one supplement he hasn’t taken in 15 years. Plus, listen to the top mistakes people make when trying to biohack their health. Dr. Mercola is a New York Times bestselling author and the founder of the natural health website Mercola.com, one of the world’s leading natural health website with millions of monthly visitors. Timestamps: (0:00) - Introduction (2:27) - The importance of the sun and Vitamin D (7:03) - Mendelian Randomization Studies with Vitamin D (10:20) - Dr. Mercola & The New York Times (11:45) - EMFs vs. Vaccines (14:25) - Tracking the effects of EMFs, Vegetable Oil, and Vaccines (15:32) - Unsullied by paid sponsors (16:00) - How long do the effects of Vegetable Oil last? (19:39) - The negative effects of Vegetable Oils (21:40) - What does Linoleic Acid do to your body? (26:34) - How Dr. Mercola changed his diet to remove vegetable oils and decrease linoleic acid (32:23) - Why studies on Vegetable Oil make it seem less harmful (34:06) - LDL Cholesterol levels (37:33) - The top 5 worst things people are doing for their health (44:37) - Iron, Ferritin, and Hemoglobin This interview is not intended as medical advice. - Check out SelfDecode - Follow Joe on Instagram