Discussing the management of advanced stage Diffuse Large B-Cell Lymphoma (DLBCL), including staging and treatment approaches. Highlights include the importance of PET CT scans, the introduction of the dose-adjusted REPOCH regimen, and the effectiveness of autologous consultative transplant in double or triple-hit lymphomas.

This week, we continue our conversation about DLBCL, this time focusing our attention on the management of early stage disease. If you have not done so, we highly recommend you listen to our hemepath series (https://www.thefellowoncall.com/rotationguide-intro-to-hematopathology) before proceeding with this episode. Furthermore, if you have not listened to the introduction to DLBCL episode (Episode 072; https://www.thefellowoncall.com/tfocpodcast/dlbclintro), we highly recommend doing so, as we will be building on these basics this week. Content: - What is the role of PET/CT in diagnosis of DLBCL?- What is the Deauville score?- How do we approach treatment to early stage DLBCL?- What are options without radiation?- What are treatment options for older patients with early stage DLBCL? **This episode is sponsored by HemOnc.org** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

This week, we kick off a new series focusing on diffuse large B-cell lymphoma. In this first episode, we discuss the basics that everyone needs to understand before diving into the management of this disease. We highly recommend listening to our hemepath series before proceeding with this DLBCL series: https://www.thefellowoncall.com/rotationguide-intro-to-hematopathologyContent: - Approach to workup for a patient with suspected lymphoma- FNA vs. Core vs. Excisional biopsy for diagnosis- Use of PET/CT for staging- How to risk-stratify patients - "Double hit" vs. "double expressor"**This episode is sponsored by HemOnc.org** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

In this podcast, they dive deeper into the pathophysiology, diagnosis, and management of heparin-induced thrombocytopenia (HIT). They discuss the risk factors and diagnostic assays for HIT, as well as practical points about its management. The podcast provides an overview of platelets and their role in blood, and explains the importance of optical density in determining SRA positivity. They also cover the challenges in diagnosing and treating HIT.

In this episode of the podcast, the hosts continue discussing von Willebrand disease (vWD), focusing on type 2 subtypes. They cover topics such as testing for suspected vWD, management strategies for type 2 vWD, different subtypes of type 2 vWD, and the approach to perioperative management. They also touch on diagnosing and subtyping vWD, types of factor products used for treatment, and understanding the characteristics and management strategies of type 2 vWD subtypes.

This podcast episode discusses Von Willebrand disease, including how to evaluate suspected cases, differentiate subtypes, and the tests to order for diagnosis. It explores the role of Von Willebrand factor in hemostasis and provides an overview of different subtypes and lab results. The desmopressin challenge is also discussed.

This week, we complete our breast cancer series, focusing on triple-negative breast cancer (TNBC). The last few months have been quite the journey! Please continue to refer to our shownotes to help navigate this complex disease treatment paradigm. Content: - What is the data about recurrence of disease of TNBC? - The history of how we got to our current standards of care - Important trials to support our current treatment paradigm** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

We are not yet done with our breast cancer series, but we could not wait to share this incredibly personal conversation with a patient with a recent breast cancer diagnosis. This week, we sit down with Kaele Leonard, who herself is a Pulmonary/Critical Care fellow at Vanderbilt University Medical Center who was diagnosed with breast cancer in her early 30s. As physicians, we don’t always get to hear what the journey through diagnosis, treatment, and follow up looks like from a patient’s perspective. We are so grateful to Dr. Leonard for opening up about this with us. Content: - The patient experience of finding out results and subsequent management - Importance of discussing fertility preservation - Financing fertility preservation - Role of “cold caps” for our patients (https://www.breastcancer.org/treatment-side-effects/hair-loss/cold-caps-scalp-cooling) - The “post-cancer crash” ** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

This week, we continue our discussion about metastatic breast cancer, focusing on HER2+ disease. Content: - What is the data about recurrence of disease of different breast cancer subtypes? - The history of how we got to our current standards of care - Important trials to support our current treatment paradigm** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

After several weeks of covering localized disease, this week, we shift our discussion to metastatic breast cancer, focusing first on ER+ disease. Content: - Importance of taking a biopsy at time of disease progression - What endocrine therapy backbone do we choose in metastatic ER+ disease?- What agents can we add to endocrine therapy for metastatic ER+ disease? - What is "visceral crisis"? ** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast