The Fellow on Call: The Heme/Onc Podcast

In the final episode of the series on prostate cancer, they discuss the treatment options for metastatic castrate-resistant prostate cancer, including targeted agents like radium-223 and lutetium-177-PSMA-617. They also explore the role of PARP inhibitors in BRCA-mutated disease and the sequencing of different treatment options.

This podcast episode discusses the treatment options for metastatic castrate sensitive prostate cancer, including the lack of guidance and biomarkers for regimen selection. It also covers the importance of germline testing, the history of prostate cancer therapy, and the choice between doublet and triplet therapy. The hosts provide a case study and explore treatment options for high-volume, castrate-sensitive metastatic prostate cancer.

Explore systemic treatment options for localized prostate cancer, including risk stratification, FDA-approved PET tracers, biochemical recurrence, castrate-sensitive vs. castrate-resistant disease, and the pivotal STAMPEDE trial. Also, delve into PSMA PET imaging, the impact of Anderson receptor antagonists, and Thanksgiving dishes as a case study backdrop.

Dr. Jacob Hall, Senior Radiation Oncology resident and Chief Resident at UNC-Chapel Hill, discusses patient selection and key terms in radiation oncology for prostate cancer. They cover the role of radiation in metastatic disease, brachytherapy, and the use of proton therapy. The podcast also includes humorous camping stories and discussions on treatment options and hypofractionation in prostate cancer radiation therapy.

Dr. Sanjay Patel, a urologic oncologist, joins the hosts to discuss prostate cancer management. They cover topics such as determining biopsy candidacy, the role of MRI in diagnosis, steps involved in a biopsy, and when additional imaging is needed. They also explore surgical approaches, when pelvic lymph node dissection is recommended, and active surveillance. The podcast provides valuable insights into the management of localized prostate cancer.

In this podcast, Vineetha Thomas, a clinical pharmacist specializing in genitourinary oncology, discusses the selection of drugs for prostate cancer, their side effects, and the role of chemotherapy. They also explore specific medications like prednisone, sipuleucel-T, radium 223, and lutetium-177. Additionally, they examine the importance of monitoring bone health in prostate cancer patients and the role of clinical pharmacists in prostate cancer treatment.

Prostate cancer is a prevalent concern for men, and this discussion dives into its complexities. Screening methods and controversial PSA testing are highlighted. The podcast also covers risk stratification using Gleason scores and staging. Local treatment options—from active surveillance to surgery—are explored. Key terminologies, such as castrate-sensitive and castrate-resistant states, are defined. The hosts set the stage for upcoming conversations with experts in the field, ensuring listeners are well-informed.

Pharmacist Renee McAllister discusses managing extravasation accidents, pharmacy operations, ideal body weight vs. AUC, giving G-CSF, and supportive care tips in hematology and oncology. They also emphasize the importance of staffing and safety checks in administering inpatient chemo, relying on primary sources for drug information, and the role of pharmacists in chemotherapy management.

The podcast discusses the basics of pharmacology in oncology, including the differences between irritants and vesicants, the need for central access in patients receiving therapy, and an overview of chemotherapy side effects.

The hosts discuss the importance of understanding chemotherapy fundamentals, counseling patients, and administering drugs. They explore treatment regimens, valuable resources, and the three main categories of chemotherapy: cytotoxic, immune, and targeted therapy. The chapter also covers important aspects of chemotherapy and previews upcoming topics.