The Fellow on Call: The Heme/Onc Podcast

The discussion centers on managing relapsed diffuse large B-cell lymphoma (DLBCL) and dives into complex treatment strategies. The hosts share insights on dealing with CNS involvement, comparing CAR-T therapy with autologous transplant options. Tailoring treatment for individual patients is emphasized, especially in elderly cases where traditional therapies might not be viable. The episode underscores the significance of innovative approaches like polituzumab-vidotin to improve outcomes, providing a rich blend of expertise and relatable anecdotes.

Explore the challenging landscape of primary refractory diffuse large B-cell lymphoma (DLBCL) management. Learn about the critical distinctions between primary refractory and relapsed disease. CAR-T therapy takes center stage, showcasing its role and the need for effective bridging strategies. A detailed case study of a patient reveals the complexities of treatment regimens. Finally, discover the importance of careful post-infusion monitoring and the advancements in managing refractory cases.

Discover the revolutionary approaches to treating hematologic malignancies, including CAR-T therapy and bispecific T-cell engagers. Learn how CAR-T cells are crafted and the vital side effects to monitor. Dive into the challenges of primary refractory disease and how advanced therapies can pave the way for new hope. Explore the convenience of off-the-shelf BiTE therapies versus personalized CAR-T processes. The discussion also highlights the role of autologous transplants in enhancing treatment outcomes for patients.

Discussing the management of advanced stage Diffuse Large B-Cell Lymphoma (DLBCL), including staging and treatment approaches. Highlights include the importance of PET CT scans, the introduction of the dose-adjusted REPOCH regimen, and the effectiveness of autologous consultative transplant in double or triple-hit lymphomas.

Explore the management of early stage Diffuse Large B-Cell Lymphoma with insights into diagnostic strategies like PET/CT scans and the Deauville score. A case study illustrates tailored treatment approaches that de-escalate therapy while ensuring effective outcomes. Discover advancements in treatment, evolving from traditional chemotherapy to modernized regimens, and how genetic factors influence decisions. Special considerations for older patients highlight the importance of personalized care in this complex field.

Dive into the complexities of diffuse large B-cell lymphoma with insights on essential diagnostic techniques like FNA and core biopsy. Discover the nuances of risk stratification, focusing on factors like age and LDH levels. Explore the significance of genetic markers in treatment decisions, including the distinctions between double hit and triple hit classifications. The hosts also share personal touches, discussing their emotional connections with patients and their favorite TV shows, adding a light-hearted break to the serious topic.

In this podcast, they dive deeper into the pathophysiology, diagnosis, and management of heparin-induced thrombocytopenia (HIT). They discuss the risk factors and diagnostic assays for HIT, as well as practical points about its management. The podcast provides an overview of platelets and their role in blood, and explains the importance of optical density in determining SRA positivity. They also cover the challenges in diagnosing and treating HIT.

In this episode of the podcast, the hosts continue discussing von Willebrand disease (vWD), focusing on type 2 subtypes. They cover topics such as testing for suspected vWD, management strategies for type 2 vWD, different subtypes of type 2 vWD, and the approach to perioperative management. They also touch on diagnosing and subtyping vWD, types of factor products used for treatment, and understanding the characteristics and management strategies of type 2 vWD subtypes.

This podcast episode discusses Von Willebrand disease, including how to evaluate suspected cases, differentiate subtypes, and the tests to order for diagnosis. It explores the role of Von Willebrand factor in hemostasis and provides an overview of different subtypes and lab results. The desmopressin challenge is also discussed.

Dive into the world of metastatic triple-negative breast cancer as experts discuss its complexities and treatment challenges. They highlight the crucial role of genetic testing and how BRCA1 mutations influence patient care. Hear about historical studies shaping current practices and the promising advancements in treatment, including immunotherapy. Emphasizing the significance of personalized approaches, this insightful conversation blends intricate medical details with relatable moments.