The Fellow on Call: The Heme/Onc Podcast

Explore warfarin and enoxaparin failure in the context of anticoagulation. Discuss alternative options for patients with anti-phospholipid antibody syndrome (APLS) whose warfarin treatment failed. Learn about distinguishing new and residual clots on imaging and the implications. Understand APLS, its impact on lab testing, and accurate diagnosis. Explore the correlation between INR values and factor 10 activity in patients with lupus anticoagulants.

This podcast discusses the workup for anticoagulation failure, focusing on DOAC failure. They explore challenges and considerations, including verifying blood thinner levels, assessing patient adherence, and exploring anatomic reasons for clot formation. They also discuss alternative anticoagulants like warfarin.

This podcast dives deep into the management of relapsed diffuse large B-cell lymphoma, exploring innovative treatments like selective antibodies against CD19. The discussions highlight exciting alternative therapies, including loncastuximab and combination regimens with tafacitimab and lenalidomide. Listeners hear about the promising results from clinical trials and the evolving strategies post-CAR-T therapy. It also evaluates the potential of allogeneic transplants in DLBCL management, painting a hopeful future for lymphoma treatments.

The discussion centers on managing relapsed diffuse large B-cell lymphoma (DLBCL) and dives into complex treatment strategies. The hosts share insights on dealing with CNS involvement, comparing CAR-T therapy with autologous transplant options. Tailoring treatment for individual patients is emphasized, especially in elderly cases where traditional therapies might not be viable. The episode underscores the significance of innovative approaches like polituzumab-vidotin to improve outcomes, providing a rich blend of expertise and relatable anecdotes.

Explore the challenging landscape of primary refractory diffuse large B-cell lymphoma (DLBCL) management. Learn about the critical distinctions between primary refractory and relapsed disease. CAR-T therapy takes center stage, showcasing its role and the need for effective bridging strategies. A detailed case study of a patient reveals the complexities of treatment regimens. Finally, discover the importance of careful post-infusion monitoring and the advancements in managing refractory cases.

Discover the revolutionary approaches to treating hematologic malignancies, including CAR-T therapy and bispecific T-cell engagers. Learn how CAR-T cells are crafted and the vital side effects to monitor. Dive into the challenges of primary refractory disease and how advanced therapies can pave the way for new hope. Explore the convenience of off-the-shelf BiTE therapies versus personalized CAR-T processes. The discussion also highlights the role of autologous transplants in enhancing treatment outcomes for patients.

Discussing the management of advanced stage Diffuse Large B-Cell Lymphoma (DLBCL), including staging and treatment approaches. Highlights include the importance of PET CT scans, the introduction of the dose-adjusted REPOCH regimen, and the effectiveness of autologous consultative transplant in double or triple-hit lymphomas.

Explore the management of early stage Diffuse Large B-Cell Lymphoma with insights into diagnostic strategies like PET/CT scans and the Deauville score. A case study illustrates tailored treatment approaches that de-escalate therapy while ensuring effective outcomes. Discover advancements in treatment, evolving from traditional chemotherapy to modernized regimens, and how genetic factors influence decisions. Special considerations for older patients highlight the importance of personalized care in this complex field.

Dive into the complexities of diffuse large B-cell lymphoma with insights on essential diagnostic techniques like FNA and core biopsy. Discover the nuances of risk stratification, focusing on factors like age and LDH levels. Explore the significance of genetic markers in treatment decisions, including the distinctions between double hit and triple hit classifications. The hosts also share personal touches, discussing their emotional connections with patients and their favorite TV shows, adding a light-hearted break to the serious topic.

In this podcast, they dive deeper into the pathophysiology, diagnosis, and management of heparin-induced thrombocytopenia (HIT). They discuss the risk factors and diagnostic assays for HIT, as well as practical points about its management. The podcast provides an overview of platelets and their role in blood, and explains the importance of optical density in determining SRA positivity. They also cover the challenges in diagnosing and treating HIT.