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The Fellow on Call: The Heme/Onc Podcast

Episode 079: Heme Consult Series: When anticoagulation fails, Part 1

Nov 1, 2023
This podcast discusses the workup for anticoagulation failure, focusing on DOAC failure. They explore challenges and considerations, including verifying blood thinner levels, assessing patient adherence, and exploring anatomic reasons for clot formation. They also discuss alternative anticoagulants like warfarin.
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Quick takeaways

  • Determining the reason for anticoagulation failure is crucial for developing an appropriate treatment plan.
  • When a patient experiences DOAC failure, switching to more potent medications like warfarin or injectable anticoagulants may be necessary.

Deep dives

Determining Reasons for Anticoagulation Failure

When a patient reports anticoagulation failure, it is important to prove that it is indeed a failure. Verify the presence of the drug in the patient's bloodstream using an anti-10A level test. Monitor the patient's medication adherence history and consider any issues that may have affected absorption. Discuss the patient's medication organization and refill habits, as well as potential factors like side effects or expense that may have impacted adherence. Additionally, evaluate for any anatomic reasons that may have led to clot formation, such as compression or tumor invasion. If anatomic causes are identified, consult with surgical or interventional services for possible correction. Overall, determining the reason for anticoagulation failure is crucial for developing an appropriate treatment plan.

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