The Fellow on Call: The Heme/Onc Podcast

Dive into the latest advancements in treating relapsed/refractory follicular lymphoma with a focus on cellular therapies like CAR T and bispecific antibodies. Discover how these therapies are manufactured and administered, plus insights into patient selection criteria. Learn about the distinct effects of cytokine release syndrome and neurotoxicity, along with detailed trial results and safety profiles. The conversation also highlights practical considerations for clinicians and the real-world application of these cutting-edge treatments.

The discussion dives into relapsed/refractory follicular lymphoma and explores non-cellular therapy options. It highlights the use of rituximab maintenance therapy and its impact on patient surveillance. The hosts analyze treatment choices for low-burden relapses, comparing lenalidomide combined with rituximab and traditional chemotherapy. Key insights include the importance of POD24 in prognosis and the clinical role of oral tazemetostat. The episode wraps up with a sneak peek into future discussions on bispecifics and CAR-T therapies.

This discussion dives deep into front-line therapies for follicular lymphoma. It unpacks management strategies for both localized and diffuse disease, assessing treatment options for symptomatic versus asymptomatic patients. The impact of rituximab therapy is evaluated, with insights from the PRIMA trial. The conversation also highlights the evolving understanding of lymphoma classifications and the role of personalized care in improving patient outcomes. Historical studies shape today's decisions, making it a compelling exploration of treatment approaches.

Explore the challenges of managing follicular lymphoma as the hosts discuss accurate biopsy techniques and the importance of tissue sampling. Discover the nuances of diagnosing various lymphoma types, particularly focusing on CD10 positivity. Delve into the classification of follicular lymphoma subtypes, including rare variants and their treatment implications. The discussion also highlights the significance of imaging techniques like PET-CT scans and effective staging systems that are critical for tailored treatment strategies.

Delve into the management of antiphospholipid antibody syndrome with insights on anticoagulants. Discover if a higher INR is indeed better for warfarin and explore the role of Direct Oral Anticoagulants. The hosts debate the optimal timing for APLS testing—don't miss their lively back-and-forth! A recent trial sheds light on transitioning patients from warfarin to rivaroxaban, scrutinizing its findings. Plus, learn about the comparative effects of apixaban and warfarin in this complex treatment landscape.

This week, the focus is on antiphospholipid antibody syndrome and its connection to venous thromboembolism. The hosts discuss the complexities of diagnosis, including the significance of specific antibody tests and the common pitfalls of false positives. A real-life case study highlights the clinical criteria necessary for accurate assessment and management. Listeners gain insights into the evolution of the syndrome's understanding and the implications for effective patient care, especially in pregnancy.

Delve into the crucial considerations of managing anticoagulation during surgeries and emergencies. Learn the importance of holding and reversing anticoagulants in various clinical scenarios. The discussion emphasizes effective communication with patients and healthcare providers to ensure safety. Discover insights on using Indexanet alpha as a reversal agent and the complexities involved in individual patient care. This informative session balances technical expertise with relatable anecdotes, making it a must-listen for medical professionals.

This week, we talk all about hypercoagulable testing - a very common referral in outpatient hematology. Who do we consider testing on? Who should we encourage not to test? We discuss this and more here. Episode contents:- What are situations in which to consider hypercoaguable testing? - What are situations to avoid doing so? **** Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

Dive into the world of venous thromboembolism (VTE) as experts unravel the essentials of diagnosis and initial management. Discover the importance of accurate imaging and the collaborative efforts among medical specialties. Learn strategies for managing pulmonary embolism and deep vein thrombosis, including advanced imaging techniques and the role of IVC filters. Unpack the complexities of anticoagulation management and the risks associated with thrombolytics. Engage with patient risk factors that shape treatment decisions!

Dr. Amar Kishan, a radiation oncologist at UCLA, sheds light on the pivotal role of radiation therapy in testicular cancer treatment. He discusses essential studies needed before radiation appointments and the planning process for seminoma patients. Key concerns such as fertility, hormonal function, and the implications of radiation are addressed. The conversation also explores emerging therapies and the benefits of proton therapy, clarifying its advantages and aiming to minimize long-term health risks for younger patients.