Explore the intricacies of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) diagnosis. Discover how bone marrow biopsy reports play a crucial role in identifying these conditions. Learn about the WHO and ICC classifications and disease-defining cytogenetic markers. Delve into a clinical case highlighting macrocytic anemia and thrombocytopenia. Unpack the challenges of interpreting pathology reports and the importance of collaborative discussions for accurate diagnoses. Stay updated on the latest diagnostic techniques and genetic implications for effective treatment.

Dive into the captivating world of myelodysplastic syndrome and acute myeloid leukemia. Discover the intriguing distinctions between CHIP, CCUS, and ICUS while unraveling the mysteries of hematopoiesis and clonality. The hosts share compelling clinical case studies that shed light on patient evaluations and the importance of bone marrow assessments. Plus, learn about the impact of variant allele frequencies and how they influence prognosis and treatment options. This conversation promises an enlightening blend of research and personal insights!

Delve into the urgent challenges of managing acute promyelocytic leukemia with insights on its diagnosis and treatment. Discover how the disease's classification as a hematologic emergency has evolved, leading to new management strategies. Listen in on a complex case highlighting critical lab findings indicative of acute leukemia. Understand the unique features of APL and the role of the PML-RARA fusion gene, along with urgent strategies addressing complications like differentiation syndrome for improved patient recovery.

Titilope Fasipe, MD, PhD, is a physician and researcher who lives with sickle cell disease while caring for patients. She shares her powerful journey from childhood to becoming a medical professional. Dr. Fasipe discusses the complexities of managing her own pain as she advocates for her patients, emphasizing the importance of empathy in healthcare. The conversation also touches on improving sickle cell care in emergency departments and the critical shift needed in perceptions about pain management, aiming to foster understanding and trust.

Dive into the chronic management of sickle cell disease, exploring the essential role of routine outpatient care and medication counseling. Discover the benefits of hydroxyurea and hear about groundbreaking new treatments like chryzminosumab and Voxelitor. The conversation also emphasizes comprehensive care, covering hydration, nutrition, and mental health strategies. Plus, insightful tips on effective preoperative transfusion practices and pain management strategies for patients add depth to this vital discussion.

Explore the urgent management of acute sickle cell complications! Discover effective strategies for treating pain crises and acute chest syndrome. Learn about hyperhemolytic crises and the implications of splenic and hepatic sequestration. Real patient cases highlight critical care interventions and the importance of monitoring. The blend of serious medical insights with relatable anecdotes makes this discussion both informative and engaging!

In this week’s episode, we discuss chronic complications that can arise in patients with sickle cell disease. The reality is, that unless we have an outpatient clinic or rotate through an outpatient clinic, there is a small chance that we will come across many of these issues. However, screening for and managing these chronic complications can have significant implications on our patients’ lives. Contents: - What are the current screening guidelines for sickle cell disease complications?- What are key studies in pediatric SCD management? - Management of stroke, avascular necrosis, pain, pulmonary hypertension, kidney disease, iron overload, and other important complications to be aware of **Have some time and want to make some extra money? Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email ** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

It’s time for another new series, this time focusing on Sickle Cell Disease! In this first episode, we lay the foundation for our future discussions. This episode can be dense, but rest assured we will revisit these concepts and expand on them throughout the series. Contents: - What is hemoglobin? - What is the underlying problem in sickle cell disease genotypically? - Why is the presence of sickled cells problematic? - What is sickle cell trait?- What are other presentations similar to sickle cell disease/HbSS? - What are common electrophoresis patterns? - What is "hereditary persistence of hemoglobin"? **Have some time and want to make some extra money? Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email ** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

This week, we round out our discussion on metastatic colorectal cancer, focusing on more targeted therapies for this disease. If you have not done so already, be sure to check out episode 107 for the first part of our metastatic colorectal cancer discussion.Contents: - What is the role of immunotherapy?- What is the role of BRAF inhibition?- Can we use HER2 targeted therapies? - What is the role of more intensive chemotherapy regiments for patients? **Have some time and want to make some extra money? Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email ** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

This week, we continue our discussion of colorectal cancer, turning our attention to metastatic disease, specifically for cancers without targetable mutations. If you have not done already, we highly recommend you check out episode 104 for our GI oncology pharmacology discussion!Contents: - What information do we need when we approach a new patient with metastatic colorectal cancer? - How did we get to our current treatment paradigm? - Is there a role for maintenance 5-FU?- What is the role of EGFR-inhibitor bevacizumab?- Why does mutational analysis matter? - Why does sidedness of the tumor matter?- Is there a role for treatment holidays?- What do we do at the time of disease progression?**This episode is sponsored by our Global Research Partners! Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email ** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast