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The Fellow on Call: The Heme/Onc Podcast
Episode 123: AML Series, Pt 9 - Introduction to Allogeneic Transplant
Dec 4, 2024
Dr. Amar Kelkar, an instructor at Harvard Medical School and specialist at Dana-Farber, joins for an enlightening dive into allogeneic transplants for AML. He unpacks key eligibility criteria for patients, stressing the importance of minimal residual disease status. The conversation also illuminates the critical role of HLA matching and donor selection factors. Additionally, Dr. Kelkar compares various stem cell sources, revealing unique insights about outcomes in haploidentical and cord blood transplants. His expert perspective makes this complex topic accessible.
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Quick takeaways
- Eligibility for allogeneic transplants relies on disease-specific factors and risk assessments, particularly for patients with acute myeloid leukemia (AML).
- HLA matching plays a critical role in optimizing transplant success, influencing donor selection and minimizing complications like graft-versus-host disease.
Deep dives
Transplant Eligibility Criteria
Determining eligibility for allogeneic transplants involves assessing both disease-specific and overall health factors. Patients with acute myeloid leukemia (AML) are categorized into risk groups, with medium and high-risk patients traditionally recommended for transplant. Recent guidelines refine these categorizations, emphasizing the importance of NPM1 and FLT3 mutations in assessing risk levels. Understanding these criteria aids in deciding the appropriateness of transplant for each patient, ensuring those most likely to benefit from transplant procedures receive them.
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