The Fellow on Call: The Heme/Onc Podcast

Dive into the intricacies of Acute Myeloid Leukemia treatment, starting with essential definitions and an overview. Learn the vital role of leukapheresis and cytoreduction when faced with high blast levels. Explore the importance of molecular testing for effective risk stratification and treatment planning. Discover the phases of AML treatment, emphasizing morphologic remission and response criteria. Tune in for a blend of clinical insights and engaging anecdotes that illuminate this complex topic.

Explore the intricacies of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) diagnosis. Discover how bone marrow biopsy reports play a crucial role in identifying these conditions. Learn about the WHO and ICC classifications and disease-defining cytogenetic markers. Delve into a clinical case highlighting macrocytic anemia and thrombocytopenia. Unpack the challenges of interpreting pathology reports and the importance of collaborative discussions for accurate diagnoses. Stay updated on the latest diagnostic techniques and genetic implications for effective treatment.

Dive into the captivating world of myelodysplastic syndrome and acute myeloid leukemia. Discover the intriguing distinctions between CHIP, CCUS, and ICUS while unraveling the mysteries of hematopoiesis and clonality. The hosts share compelling clinical case studies that shed light on patient evaluations and the importance of bone marrow assessments. Plus, learn about the impact of variant allele frequencies and how they influence prognosis and treatment options. This conversation promises an enlightening blend of research and personal insights!

Delve into the urgent challenges of managing acute promyelocytic leukemia with insights on its diagnosis and treatment. Discover how the disease's classification as a hematologic emergency has evolved, leading to new management strategies. Listen in on a complex case highlighting critical lab findings indicative of acute leukemia. Understand the unique features of APL and the role of the PML-RARA fusion gene, along with urgent strategies addressing complications like differentiation syndrome for improved patient recovery.

Titilope Fasipe, MD, PhD, is a physician and researcher who lives with sickle cell disease while caring for patients. She shares her powerful journey from childhood to becoming a medical professional. Dr. Fasipe discusses the complexities of managing her own pain as she advocates for her patients, emphasizing the importance of empathy in healthcare. The conversation also touches on improving sickle cell care in emergency departments and the critical shift needed in perceptions about pain management, aiming to foster understanding and trust.

Dive into the chronic management of sickle cell disease, exploring the essential role of routine outpatient care and medication counseling. Discover the benefits of hydroxyurea and hear about groundbreaking new treatments like chryzminosumab and Voxelitor. The conversation also emphasizes comprehensive care, covering hydration, nutrition, and mental health strategies. Plus, insightful tips on effective preoperative transfusion practices and pain management strategies for patients add depth to this vital discussion.

Explore the urgent management of acute sickle cell complications! Discover effective strategies for treating pain crises and acute chest syndrome. Learn about hyperhemolytic crises and the implications of splenic and hepatic sequestration. Real patient cases highlight critical care interventions and the importance of monitoring. The blend of serious medical insights with relatable anecdotes makes this discussion both informative and engaging!

Explore the chronic complications of sickle cell disease, emphasizing the need for awareness among healthcare providers. Discover screening guidelines and the management of issues like stroke and pulmonary hypertension. Learn about groundbreaking studies in pediatric care and the role of hydroxyurea. Understand the implications of sickle cell nephropathy and the importance of early screenings. This discussion highlights multi-faceted care strategies to improve patients' lives.

Dive into the basics of Sickle Cell Disease! Explore the fascinating science behind hemoglobin and the genetic mutations that create sickled cells. Discover the challenges of managing this condition through real-life case studies. Learn about the crucial differences between sickle cell disease and trait, plus the role of hemoglobin electrophoresis in diagnosis. This engaging introduction sets the stage for a deeper understanding of patient outcomes and implications for care.

Dive into the intricate world of metastatic colorectal cancer with a focus on innovative treatments! Discover the impact of immunotherapy and the promising role of BRAF inhibition. Learn how HER2 targeted therapies, like trastuzumab and tucatinib, are changing the landscape of care for specific patient groups. The discussion also highlights the importance of MMR and MSI testing in tailoring immunotherapy responses, underscoring the trend towards personalized medicine for better outcomes.