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The Fellow on Call: The Heme/Onc Podcast
Episode 116: AML Series, Pt. 2 - MDS/AML Diagnosis and Risk Stratification
Sep 18, 2024
Explore the intricacies of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) diagnosis. Discover how bone marrow biopsy reports play a crucial role in identifying these conditions. Learn about the WHO and ICC classifications and disease-defining cytogenetic markers. Delve into a clinical case highlighting macrocytic anemia and thrombocytopenia. Unpack the challenges of interpreting pathology reports and the importance of collaborative discussions for accurate diagnoses. Stay updated on the latest diagnostic techniques and genetic implications for effective treatment.
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Quick takeaways
- Bone marrow biopsy is pivotal for diagnosing MDS and AML, focusing on cytogenetic analysis to evaluate prognosis and treatment pathways.
- Understanding the evolving diagnostic criteria and genetic mutations is essential for accurate risk stratification and personalized management strategies in hematology.
Deep dives
Understanding Bone Marrow Biopsy Interpretation
Bone marrow biopsy is essential in diagnosing and evaluating myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). The biopsy involves obtaining both liquid samples and solid core samples to assess cellular morphology and identify abnormalities. Key components include the aspirate for flow cytometry, cytogenetics, and molecular studies, along with the core biopsy for cellular architecture and immunophenotyping. Accurate interpretation is crucial, as dysplasia and blast counts significantly influence diagnosis and risk stratification for these hematological conditions.
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