The Fellow on Call: The Heme/Onc Podcast

Dive into the basics of Sickle Cell Disease! Explore the fascinating science behind hemoglobin and the genetic mutations that create sickled cells. Discover the challenges of managing this condition through real-life case studies. Learn about the crucial differences between sickle cell disease and trait, plus the role of hemoglobin electrophoresis in diagnosis. This engaging introduction sets the stage for a deeper understanding of patient outcomes and implications for care.

Dive into the intricate world of metastatic colorectal cancer with a focus on innovative treatments! Discover the impact of immunotherapy and the promising role of BRAF inhibition. Learn how HER2 targeted therapies, like trastuzumab and tucatinib, are changing the landscape of care for specific patient groups. The discussion also highlights the importance of MMR and MSI testing in tailoring immunotherapy responses, underscoring the trend towards personalized medicine for better outcomes.

Dive into the complexities of metastatic colorectal cancer treatment options! Discover the significance of personalized approaches, including the roles of Bevacizumab and EGFR inhibitors. Learn why mutational analysis and tumor sidedness are crucial in managing this disease. The discussion features a compelling case study that highlights advancements in chemotherapy regimens and patient-centered care. Expect a mix of serious insights and light-hearted moments, like a humorous cowboy boot anecdote!

Dive into the complexities of anticoagulation failures and discover alternative strategies when conventional treatments falter. Explore the challenges faced by patients on warfarin, including diagnosing new clots and the importance of imaging. Learn about managing anticoagulation in conditions like antiphospholipid antibody syndrome, with a focus on diagnostic testing and INR interpretation. The podcast also emphasizes tailored Lovenox dosing and monitoring drug levels to tackle breakthrough thrombotic events. It's a blend of medical insights and a delightful sandwich shop interlude!

Discover the intriguing world of anticoagulation as the hosts dive into the challenges of medication failures. They explore case studies illustrating why some patients still encounter blood clots, even while on treatment. Learn about the significance of monitoring drug levels and the impact of patient adherence on therapy success. The conversation also touches on when to pivot to traditional anticoagulants like warfarin, bringing a blend of clinical insights and personal anecdotes to keep the discussions engaging and informative!

Dive into the intriguing world of heparin-induced thrombocytopenia (HIT) and its variants! Learn the critical diagnostic tests like ELISA and SRA that differentiate HIT from other conditions. Hear a compelling case study about postoperative challenges in managing anticoagulation. Discover the vital roles of platelets and the 4T score in diagnosing HIT. Also, uncover essential strategies for safely managing HIT patients and the importance of monitoring anticoagulation transitions. Perfect for new hematology/oncology fellows gearing up for their roles!

Join neurosurgeon Josh Lowenstein as he dives into the complexities of spinal cord compression in oncology. He discusses the differential diagnosis for various cancers, including breast and prostate cancer. Learn about the acute management strategies, like steroid use, and how crucial it is to involve radiation oncologists in care decisions. Lowenstein also highlights advancements in radiation therapy, including SBRT and SRS, and explores radion sensitivity differences among tumors, emphasizing a collaborative approach in patient management.

Ryan Miller, a fourth-year radiation oncology resident at Thomas Jefferson University, discusses the critical role of radiation in managing Superior Vena Cava (SVC) syndrome. Rupal Parikh, training in interventional radiology at the University of Pennsylvania, shares her insights on therapeutic interventions for this urgent condition. They emphasize the importance of multidisciplinary collaboration in treatment, explore diagnostic strategies, and highlight the balance between immediate care and long-term management for patients.

Dive into the intricacies of metastatic cancer with unknown origins, featuring personal insights and the importance of precise biopsy options. Enjoy a case study journey that showcases collaborative oncology consults. Learn about the necessity of advanced imaging techniques, including PET and CT scans, to improve diagnosis. Understand the emotional challenges faced by patients in the interim of diagnosis to treatment planning, highlighting the need for comprehensive care and accurate information in oncology.

As the new academic year begins, the focus is on preparing hematology/oncology fellows for their first on-call nights. The discussion covers critical topics like the workup for thrombocytopenia, distinguishing ITP from TTP, and the various diagnostic strategies. Key treatment options for ITP are explored, including the use of IVIG and corticosteroids. A unique take on the immature platelet fraction highlights its role in assessing bleeding risk, ensuring fellows are equipped with essential knowledge for managing hematologic emergencies.