The Fellow on Call: The Heme/Onc Podcast

Dive into the complexities of managing relapsed chronic lymphocytic leukemia (CLL) with insights on treatment strategies and patient care. Discover the challenges of diagnosing Richter's transformation and the impact of key therapies like obinutuzumab and venetoclax. Learn about the significance of genetic markers in prognosis and the evolving landscape of second-line treatments, including the implications of recent market withdrawals. Nostalgic discussions about childhood animated films add a light-hearted touch to this serious topic.

Delve into the latest advancements in chronic lymphocytic leukemia treatment, exploring crucial indications for therapy and the debate between fixed versus indefinite options. A complex case study reveals the challenges faced by a patient with multiple health issues. Discover the intricacies of managing associated autoimmune conditions and the significance of monitoring approaches. Key insights on novel therapies, including BTK inhibitors and venetoclax, are shared, shedding light on personalized treatment strategies and their implications for patient care.

Dive into the world of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) as the hosts share personal clinical experiences. Discover insights about diagnosing CLL, the mystery of smudge cells, and the importance of B cells. They debunk common myths and emphasize that patients can often live well without aggressive treatment. Plus, explore advancements in risk stratification and the role of molecular testing in tailored patient care. And don’t miss out on some recommended winter wines to enjoy while you listen!

Exploring Cold Agglutinin Disease and other acquired hemolytic anemias, the podcast covers diagnosis, management, and advancements in treatments like rituximab. It also delves into PNH, spursal anemia, and medication-induced hemolytic anemia, emphasizing the importance of personalized treatment plans and medication reconciliation.

Explore the complexities of managing warm autoimmune hemolytic anemia, from diagnostic workups to treatment strategies. Learn about challenges with blood transfusions, early connection with the blood bank, and using immune suppression for long-term remission. Dive into case studies, treatment approaches using retuximab and steroids, and monitoring parameters for non-responsive cases. Discover post-treatment care, tapering steroids, and alternative therapies for relapse and refractory cases.

Explore rare inherited conditions causing hemolytic anemia, including membranopathies and enzyme deficiencies. Learn about hereditary spherocytosis, hereditary elliptocytosis, G6PD deficiency, and PK deficiency. Discover diagnosis and treatment considerations for these disorders, and recent advances in treatment options.

The podcast discusses hemolytic anemias, including the workup for acquired hemolytic anemias and G6PD deficiency. They cover when to suspect these conditions and the importance of tailored clinical assessment and management strategies.

In the final episode of the series on prostate cancer, they discuss the treatment options for metastatic castrate-resistant prostate cancer, including targeted agents like radium-223 and lutetium-177-PSMA-617. They also explore the role of PARP inhibitors in BRCA-mutated disease and the sequencing of different treatment options.

This podcast episode discusses the treatment options for metastatic castrate sensitive prostate cancer, including the lack of guidance and biomarkers for regimen selection. It also covers the importance of germline testing, the history of prostate cancer therapy, and the choice between doublet and triplet therapy. The hosts provide a case study and explore treatment options for high-volume, castrate-sensitive metastatic prostate cancer.

Explore systemic treatment options for localized prostate cancer, including risk stratification, FDA-approved PET tracers, biochemical recurrence, castrate-sensitive vs. castrate-resistant disease, and the pivotal STAMPEDE trial. Also, delve into PSMA PET imaging, the impact of Anderson receptor antagonists, and Thanksgiving dishes as a case study backdrop.