The Fellow on Call: The Heme/Onc Podcast

Dive into the intricacies of adjuvant therapy for Stage III colon cancer. Learn about essential chemotherapy regimens, FOLFOX and CAPOX, and when to use them. Discover the significance of treatment duration and the implications of high-risk factors. Explore the evolution of chemotherapy and how capecitabine plays a role in enhancing outcomes. The impact of mismatch repair status on treatment effectiveness adds another layer to this complex discussion, making for a compelling listen on the management and patient care in colon oncology.

Colorectal cancer is one of the most common cancers diagnosed each year worldwide. This highly anticipated series will take an in-depth look at this disease. In this first episode, we discuss the basics, including staging, tumor markers, and microsatellite instability testing, before tackling the management of colorectal cancer in upcoming episodes. Content: - What is the incidence of colorectal cancer (CRC) in the US?- How are CRC patients staged? - What is the role of CEA? - What are microsatellites and mismatch repair proteins, and how do they come into play for treatment purposes?- Who needs germline testing? - What is the TNM staging for CRC? - What are some high risk factors we need to pay attention to on the pathology report? ** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

Delve into the fascinating world of minimal residual disease (MRD) testing in chronic lymphocytic leukemia (CLL). Discover how MRD plays a pivotal role in treatment decisions, the advanced techniques for detection, and the implications of MRD status on patient outcomes. Tune in for insights about the efficacy of methods like flow cytometry and the Clonosec assay, and learn about ongoing research that might reshape treatment strategies. Plus, enjoy a mix of medical insights and entertaining commentary that keeps the conversation lively!

Dive into the complexities of managing relapsed chronic lymphocytic leukemia (CLL) with insights on treatment strategies and patient care. Discover the challenges of diagnosing Richter's transformation and the impact of key therapies like obinutuzumab and venetoclax. Learn about the significance of genetic markers in prognosis and the evolving landscape of second-line treatments, including the implications of recent market withdrawals. Nostalgic discussions about childhood animated films add a light-hearted touch to this serious topic.

Delve into the latest advancements in chronic lymphocytic leukemia treatment, exploring crucial indications for therapy and the debate between fixed versus indefinite options. A complex case study reveals the challenges faced by a patient with multiple health issues. Discover the intricacies of managing associated autoimmune conditions and the significance of monitoring approaches. Key insights on novel therapies, including BTK inhibitors and venetoclax, are shared, shedding light on personalized treatment strategies and their implications for patient care.

Dive into the world of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) as the hosts share personal clinical experiences. Discover insights about diagnosing CLL, the mystery of smudge cells, and the importance of B cells. They debunk common myths and emphasize that patients can often live well without aggressive treatment. Plus, explore advancements in risk stratification and the role of molecular testing in tailored patient care. And don’t miss out on some recommended winter wines to enjoy while you listen!

Exploring Cold Agglutinin Disease and other acquired hemolytic anemias, the podcast covers diagnosis, management, and advancements in treatments like rituximab. It also delves into PNH, spursal anemia, and medication-induced hemolytic anemia, emphasizing the importance of personalized treatment plans and medication reconciliation.

Explore the complexities of managing warm autoimmune hemolytic anemia, from diagnostic workups to treatment strategies. Learn about challenges with blood transfusions, early connection with the blood bank, and using immune suppression for long-term remission. Dive into case studies, treatment approaches using retuximab and steroids, and monitoring parameters for non-responsive cases. Discover post-treatment care, tapering steroids, and alternative therapies for relapse and refractory cases.

Explore rare inherited conditions causing hemolytic anemia, including membranopathies and enzyme deficiencies. Learn about hereditary spherocytosis, hereditary elliptocytosis, G6PD deficiency, and PK deficiency. Discover diagnosis and treatment considerations for these disorders, and recent advances in treatment options.

The podcast discusses hemolytic anemias, including the workup for acquired hemolytic anemias and G6PD deficiency. They cover when to suspect these conditions and the importance of tailored clinical assessment and management strategies.