The Fellow on Call: The Heme/Onc Podcast cover image

The Fellow on Call: The Heme/Onc Podcast

Episode 093: Heme Consult Series: Warm Autoimmune Hemolytic Anemia

Feb 14, 2024
Explore the complexities of managing warm autoimmune hemolytic anemia, from diagnostic workups to treatment strategies. Learn about challenges with blood transfusions, early connection with the blood bank, and using immune suppression for long-term remission. Dive into case studies, treatment approaches using retuximab and steroids, and monitoring parameters for non-responsive cases. Discover post-treatment care, tapering steroids, and alternative therapies for relapse and refractory cases.
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Quick takeaways

  • The workup of warm autoimmune hemolytic anemia includes CBC, CMP, and reticulocyte count to confirm anemia and assess cell turnover.
  • Treatment of warm autoimmune hemolytic anemia involves rituximab and steroids to suppress abnormal B cell activity and monitoring for hemolysis markers.

Deep dives

Understanding Warm Autoimmune Hemolytic Anemia

Warm autoimmune hemolytic anemia is a serious and frightening condition characterized by acquired hemolysis. Patients may present with symptoms like fatigue, dyspnea, and pallor. Initial workup includes CBC, CMP, and reticulocyte count to confirm anemia and assess cell turnover. Elevated reticulocytes and bilirubin, along with positive DAT for IgG, suggest warm autoimmune hemolysis.

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