The Fellow on Call: The Heme/Onc Podcast Episode 091: Heme Consult Series: Intro to Acquired Hemolytic Anemia and G6PD Deficiency
11 snips
Feb 6, 2024 The podcast discusses hemolytic anemias, including the workup for acquired hemolytic anemias and G6PD deficiency. They cover when to suspect these conditions and the importance of tailored clinical assessment and management strategies.
AI Snips
Chapters
Transcript
Episode notes
Always Rule Out Bleeding First
- Rule out bleeding first when evaluating an acute anemia before assuming hemolysis.
- Use focused history to check for recent surgery, transfusion, medications, or family history that might explain the drop in hemoglobin.
Postop Patient With Pyridium-Triggered Hemolysis
- A 65-year-old man developed jaundice and hemoglobin drop after starting pyridium post-op.
- He presented with elevated LDH, indirect bilirubin, high reticulocyte fraction, undetectable haptoglobin, and was ultimately diagnosed outpatient with G6PD deficiency.
DAT Is A Binding Test, Not Proof Of Cause
- The DAT identifies antibodies or complement on RBCs but does not prove those antibodies are causing hemolysis.
- Interpret DAT with clinical context and other hemolysis labs rather than as a standalone diagnostic test.