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The Fellow on Call: The Heme/Onc Podcast
Episode 094: Heme Consult Series: Cold Agglutinin Disease
Feb 21, 2024
Exploring Cold Agglutinin Disease and other acquired hemolytic anemias, the podcast covers diagnosis, management, and advancements in treatments like rituximab. It also delves into PNH, spursal anemia, and medication-induced hemolytic anemia, emphasizing the importance of personalized treatment plans and medication reconciliation.
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Quick takeaways
- Cold agglutinin disease is triggered by cold exposure, with IgM antibodies destroying red blood cells.
- Treatment for cold agglutinin disease involves avoiding cold exposure and monitoring thermal amplitude for management.
Deep dives
Understanding Cold Agglutinin Disease and Its Diagnosis
Cold agglutinin disease is a rare form of acquired hemolytic anemia where IgM antibodies lead to the destruction of red blood cells, triggered in this case by cold exposure. A case study involving a 72-year-old female with typical symptoms like fatigue, dyspnea, and rash, illustrated the diagnostic process involving laboratory tests like CBC and reticulocyte count. Peripheral smear analysis and direct antiglobulin testing confirmed the presence of IgM antibodies, characteristic of cold agglutinin disease.
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Discover
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