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16min chapter
Episode 094: Heme Consult Series: Cold Agglutinin Disease
The Fellow on Call: The Heme/Onc Podcast
Cold Agglutinin Disease: Diagnosis and Management
This chapter explores the rare autoimmune condition of Cold Agglutinin Disease (CAD), delving into its pathophysiology and diagnostic approach. It discusses how IgM antibodies target red blood cells in cold temperatures, leading to complement activation and hemolysis. The chapter also covers the importance of thermal amplitude testing, antibody titers, and management strategies like patient warming and blood warmers during transfusion.
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