Two Onc Docs

This week, explore the intricacies of hemophilia A and B, including their causes linked to clotting factors. Discover groundbreaking advancements in treatment, with a focus on recent gene therapies that are changing patient management strategies. Learn about the challenges of inhibitors and their implications in surgical contexts. Delve into diagnostic procedures and gain insight into tailored treatment options for acquired hemophilia, enhancing your understanding of this complex condition.

This week’s episode will be discussing updates from ASCO 2024 next with the practice changing NADINA trial presented on the Sunday of ASCO by Dr. Christian Blank during the plenary sessions:  A multicenter, randomized, phase 3 trial comparing the efficacy of neoadjuvant ipilimumab plus nivolumab with standard adjuvant nivolumab in macroscopic resectable stage III melanoma. We discuss the staging and prior standard of treatment for locally advanced melanoma, key findings from NADINA, and how these data may impact clinical practice.

Dive into vital cancer screening guidelines for internal medicine board exams! Learn about essential prevention strategies through real-life case studies. Discover the significance of recognizing oncological emergencies like neutropenic fever. Explore management techniques for various cancers, including genetic testing and tailored treatments. Plus, gain insights on survivorship challenges faced by cancer survivors and effective study strategies for exam prep.

Get ready to ace your hematology questions! Explore essential insights on disorders like aplastic anemia and the intricacies of multiple myeloma diagnosis and management. Delve into myelodysplastic syndrome with a case study that highlights crucial testing. Learn about vitamin B12 deficiency and management strategies for acute promyelocytic leukemia. Finally, unpack bleeding disorders and the critical aspects of transfusion reactions, all with practical tips for your upcoming boards!

This podcast covers infusion reactions in hematology and oncology, including symptoms, treatments, and common drugs causing reactions. They discuss hypersensitivity types, management strategies, and specific drugs like taxanes, platinums, and monoclonal antibodies. The episode provides insights on monitoring, consulting specialists, and guidelines for re-challenging patients.

This podcast delves into high-yield topics on oncologic emergencies for new fellows and residents, covering brain metastases, hypercalcemia, cord compression, and SVC syndrome. They discuss management strategies like steroids, fluids, bisphosphonates, and RANK L inhibitors, emphasizing the importance of timely interventions for optimal patient care.

Dr. Spigel presents the ADRIATIC trial at ASCO 2024 focusing on Durvalumab in LS-SCLC. Topics include staging imaging, treatment approaches, trial results with improved outcomes, and future trials in small cell lung cancer space.

Dr Shikha Jain, founder of Women in Medicine & GI oncologist, shares tips for new doctors & attendings. Topics include teamwork in hospitals, importance of self-care, delivering bad news, continuous learning in medicine, essential tips for new doctors & attendings, and guidance for those in oncology.

Dr. Catherine Lai from UPenn discusses AML treatment options, including chemotherapy regimens based on core binding factors, variations in toxicity, and advancements like Gemtuzumab. She also explores recovery strategies, repeatable marrow biopsies, and different treatment approaches based on risk categories and patient fitness levels. The podcast ends with key takeaways on AML diagnosis criteria, induction regimens, specific treatment options for mutations, and the importance of seeking feedback.

Dr. Catherine Lai discusses AML classification, genetic mutations, and risk factors. Topics include treatment-related factors, hereditary myeloid malignancies, and managing leukostasis and tumor lysis syndrome in leukemia.