Two Onc Docs
Infusion Reactions
Jul 22, 2024
This podcast covers infusion reactions in hematology and oncology, including symptoms, treatments, and common drugs causing reactions. They discuss hypersensitivity types, management strategies, and specific drugs like taxanes, platinums, and monoclonal antibodies. The episode provides insights on monitoring, consulting specialists, and guidelines for re-challenging patients.
12:34
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Quick takeaways
- Different classes of drugs such as taxanes and monoclonal antibodies commonly cause infusion reactions, highlighting the importance of understanding drug-specific risks.
- Early detection of infusion reactions is crucial due to the diverse range of symptoms affecting various body systems, requiring prompt intervention to prevent severe outcomes.
Deep dives
Types of Hypersensitivity Reactions and Mechanisms
There are four types of hypersensitivity reactions discussed: immediate hypersensitivity (type 1) involving IgE and histamines, antibody-mediated hypersensitivity (type 2), and cell-mediated hypersensitivity (type 4) causing reactions like contact dermatitis. Each type has distinct mechanisms, with symptoms ranging from cutaneous, respiratory, cardiovascular, to GI, requiring early detection to prevent severe reactions.
