Two Onc Docs

Dive into the latest updates on chronic lymphocytic leukemia treatment options! The discussion centers around the BRUIN-CLL 313 trial, comparing pirtobrutinib to the classic bendamustine/rituximab regimen. Key findings highlight a remarkable 24-month progression-free survival rate of 93.4% with pirtobrutinib. Explore the safety profile, common toxicities, and the implications for clinical practice. Plus, join in on the exciting future directions for CLL treatments involving novel agents and combination strategies!

This week’s episode will be focusing on gastrointestinal stromal tumors, known as GIST with a 2025 update. We will go over important details on the diagnosis, mutations, and treatment of local and metastatic GISTs.  

The podcast dives into the latest updates on Hodgkin Lymphoma, covering critical aspects like its pathology and staging. It highlights the differences between classical and nodular lymphocyte-predominant types and discusses the significance of Deauville PET scoring in treatment evaluation. There’s a thorough exploration of chemotherapy regimens, including the potential of immunotherapy for advanced stages. Additionally, the episode addresses long-term survivorship issues, from late effects to fertility and cardiopulmonary concerns.

Get the latest scoop on anal cancer with key discussions on risk factors like HPV and smoking. Learn about the crucial diagnostic steps, including imaging and node biopsies. The hosts break down staging definitions and the proven Nigro protocol for localized disease. Discover the promising results of the PODIUM-303 trial, featuring the new retifanlimab combo therapy. They also delve into ongoing trials and innovations in treatment strategies, making this a must-listen for anyone interested in the latest in cancer care!

This discussion dives into groundbreaking updates from the recent ESMO conference on bladder cancer. Key trials like POTOMAC reveal the benefits of adding immunotherapy to traditional treatments. The potential implications for cystectomy decisions are explored, particularly for non-muscle invasive bladder cancer. With significant advances in metastatic disease trials, the conversation highlights the importance of biomarker testing and innovative approaches, including ctDNA-guided therapy and promising new drug combinations.

Dive into the nuances of hematology and oncology board exams with valuable insights. Learn effective study strategies, including prioritizing high-yield topics and using cheat sheets. Discover staging and treatment options for non-small cell lung cancer, as well as the latest in breast cancer therapy. Gain clarity on critical conditions like von Willebrand disease and congenital bone marrow syndromes. The hosts also discuss research ethics and supportive care essentials, ensuring you're fully prepared for the challenge ahead!

Discover the intriguing link between porphyrias and vampire folklore, with tales of photosensitivity and garlic aversion that inspired myths! Learn about key porphyrias, their triggers, and how they're diagnosed and treated. Explore the management of chronic forms and the rare congenital types. Whether you're preparing for exams or fascinated by these mysterious diseases, this conversation provides crucial insights and fun Halloween connections!

Delve into cutting-edge advancements in metastatic breast cancer treatment. Frontline options for ER/PR-positive patients and the intricacies of CDK4/6 inhibitors are discussed. Key insights on HER2-positive regimens reveal exciting trial data. Triple-negative challenges are tackled with biomarker testing and promising therapies. Learn about the role of bone protective agents in care strategies. The hosts wrap up with practical treatment algorithms and reminders for optimal patient management.

Explore the latest in localized breast cancer treatments with 2025 updates! Discover when radiation can be skipped after surgery and the role of neoadjuvant therapies. Delve into the complexities of treating triple negative disease, including chemotherapy and the use of carboplatin. Understand hormonal therapies for ER/PR positive cases, their potential side effects, and the importance of genomic testing. Plus, insights on managing breast cancer in men and during pregnancy provide a comprehensive view of contemporary care options.

October marks Breast Cancer Awareness Month, making this a timely discussion. Key topics include breast cancer risk factors, when to get genetic testing, and screening recommendations for high-risk individuals. They delve into the management of LCIS and DCIS, detailing treatment options like mastectomy versus lumpectomy. Insights on chemoprevention, tamoxifen's side effects, and the challenges of rare breast histologies are also explored. Plus, learn the basics of staging and when axillary dissection is necessary.